IMPDH2's Central Role in Cellular Growth and Diseases: A Potential Therapeutic Target

  • Cell Prolif. 2025 Jun;58(6):e70031. doi: 10.1111/cpr.70031.
Zheng Li  1 ,  Yunpeng Zou  2 ,  Jiayao Niu  1 ,  Ying Zhang  1 ,  Aohua Yang  3 ,  Wenyu Lin  1 ,  Jie Guo  1 ,  Shuya Wang  1 ,  Ronghan Liu  1
Affiliations
  • 1. Central Hospital Affiliated to Shandong First Medical University, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
  • 2. School of Clinical Medicine, Shandong Second Medical University, Weifang, China.
  • 3. Department of Orthodontics, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, China.
PMID: 40251939 DOI: 10.1111/cpr.70031
Abstract

IMPDH2 is a rate-limiting enzyme in guanine nucleotide biosynthesis. It plays diverse roles in various physiological and pathological processes: nucleotide metabolism, inflammation, immune function, ribosomal stress. Structural or regulatory alterations in IMPDH2 are linked to significant health issues, and critical relevance in disease progression. We aim to underscore the potential of IMPDH2 as a promising therapeutic target for clinical applications.