Targeting immunosenescence and inflammaging: advancing longevity research

  • Exp Mol Med. 2025 Sep;57(9):1881-1892. doi: 10.1038/s12276-025-01527-9.
Thi Quynh Trang Nguyen  1  2 ,  Kyung A Cho  3  4  5
Affiliations
  • 1. Department of Biochemistry, Chonnam National University Medical School, Hwasun-gun, Republic of Korea.
  • 2. Center for Creative Biomedical Scientists, Chonnam National University Medical School, Hwasun-gun, Republic of Korea.
  • 3. Department of Biochemistry, Chonnam National University Medical School, Hwasun-gun, Republic of Korea. [email protected].
  • 4. Center for Creative Biomedical Scientists, Chonnam National University Medical School, Hwasun-gun, Republic of Korea. [email protected].
  • 5. MediSpan Inc., Bundang-gu, Republic of Korea. [email protected].
PMID: 40887496 DOI: 10.1038/s12276-025-01527-9
Abstract

Here we examine the crucial role of the immune system in aging, with a particular focus on two interconnected processes: immunosenescence and inflammaging, which contribute to age-related decline. Our goal is to provide a thorough overview of the various factors that lead to immune aging while introducing therapeutic approaches that can partially restore immune function. Additionally, we discuss recent strategies that go beyond localized immune improvement to actively modulate immune balance, influencing systemic aging and extending healthspan. Through this exploration, we propose that regulating the immune system is essential for managing immune aging and may serve as a key mechanism for controlling the overall aging process and promoting healthy longevity.