Antiandrogen. II. Oxygenated 2-oxapregnane steroids

  • Chem Pharm Bull (Tokyo). 1993 May;41(5):870-5. doi: 10.1248/cpb.41.870.
S Takegawa  1 ,  N Koizumi ,  H Takahashi ,  K Shibata
Affiliations
  • 1. Research Department of Teikoku Hormone Mfg. Co., Ltd., Kawasaki, Japan.
PMID: 7687931 DOI: 10.1248/cpb.41.870
Abstract

Oxygenated derivatives of 2-oxachlormadinone acetate (17-acetoxy-6-chloro-2-oxapregna-4,6-diene-3,20-dione) at C11, C15, and C16 were prepared as potential antiandrogenic agents. Biological evaluation showed the 15 beta-hydroxyl compound to have a high potent antiandrogenic activity when tested in the castrated male rat.

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