New glycosidases inhibitors, panosialins D and wD produced by Streptomyces sp. OH-5186

  • J Antibiot (Tokyo). 1995 Mar;48(3):205-10. doi: 10.7164/antibiotics.48.205.
H Yamada  1 ,  K Shiomi ,  Q Xu ,  T Nagai ,  M Shibata ,  I Oya ,  Y Takahashi ,  S Omura
Affiliations
  • 1. Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
PMID: 7730153 DOI: 10.7164/antibiotics.48.205
Abstract

New panosialin analog, panosialins D and wD have been isolated from the culture broth of Streptomyces sp. OH-5186. Their structures were elucidated as 5-(13-methylpentadecyl)-1,3-benzenediol bis(sodium sulfate) and 5-(13-methylpentadecyl)-1,3-benzenediol 1-(sodium sulfate), respectively. They showed strong inhibitory activity against alpha-mannosidase, alpha-glucosidase, and beta-glucosidase. Panosialins wA-wD mixture also showed weak mitogenic activity but suppressed the mitogen induced activity.

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