Inhibition of kainic acid binding to glutamate receptors by extracts of Gastrodia

  • Phytochemistry. 1995 Mar;38(4):835-6. doi: 10.1016/0031-9422(94)00771-k.
M Andersson  1 ,  O Bergendorff ,  M Nielsen ,  O Sterner ,  R Witt ,  J Ai ,  A Lu ,  A M Wang
Affiliations
  • 1. Department of Biochemistry, Sct. Hans Hospital, Roskilde, Denmark.
PMID: 7766386 DOI: 10.1016/0031-9422(94)00771-k
Abstract

S-(4-hydroxybenzyl)glutathione was isolated as the major principle responsible for the inhibition of the in vitro binding of kainic acid to brain glutamate receptors by water extracts of the plant Gastrodia elata. The affinity (IC50 value) of the compound is slightly lower compared to glutamate and glutathione.

Products