Pharmacokinetics of diphemanil methylsulphate in infants

  • Eur J Clin Pharmacol. 1993;45(1):89-91. doi: 10.1007/BF00315356.
A M Vidal  1 ,  G Chéron ,  E Rey ,  G Pons ,  P d'Athis ,  G Olive
Affiliations
  • 1. Département de Pharmacologie Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, Paris, France.
PMID: 8405036 DOI: 10.1007/BF00315356
Abstract

The pharmacokinetics of diphemanil methylsulphate was evaluated after oral administration of a single 3 mg.kg-1 dose to 5 infants being treated for symptomatic bradycardia. The mean pharmacokinetic parameters of oral diphemanil methylsulphate in infants were similar to those in adults. The mean half-life was 8.6 h. This would allow administration three times a day in infants instead of four to six times a day, as currently prescribed. The mean residence time decreases significantly with age (Spearman's r' = -1), and there is a trend for the half-life to decrease with age (r' = -0.9; NS), suggesting an influence of maturation on its elimination.

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