Studies on new antitumor antibiotics, leptofuranins A, B, C and D.I. Taxonomy, fermentation, isolation and biological activities

  • J Antibiot (Tokyo). 1996 Oct;49(10):974-9. doi: 10.7164/antibiotics.49.974.
Y Hayakawa  1 ,  K Sohda ,  K Furihata ,  T Kuzuyama ,  K Shin-ya ,  H Seto
Affiliations
  • 1. Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
PMID: 8968389 DOI: 10.7164/antibiotics.49.974
Abstract

The retinoblastoma protein (pRB) is inactivated in a wide variety of human cancers. In the course of our screening for antitumor Antibiotics by using pRB-inactivated cells, an actinomycete identified as Streptomyces tanashiensis was found to produce four new active substances, leptofuranins A, B, C and D. The leptofuranins arrested the growth of normal cells and induced apoptotic cell death against tumor cells and cells transformed with the adenovirus E1A gene.

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