Increased plasma amyloid beta protein 1-42 levels in Down syndrome

  • Neurosci Lett. 1998 Jan 23;241(1):13-6. doi: 10.1016/s0304-3940(97)00966-x.
P D Mehta  1 ,  A J Dalton ,  S P Mehta ,  K S Kim ,  E A Sersen ,  H M Wisniewski
Affiliations
  • 1. Department of Immunology, New York State Institute for Basic Research, Staten Island 10314-6399, USA. [email protected]
PMID: 9502204 DOI: 10.1016/s0304-3940(97)00966-x
Abstract

Amyloid beta protein 1-40 (A beta40) and A beta42 levels were quantitated in plasma from 43 persons with Down syndrome (DS; 26-68 years of age), 43 age-matched normal controls, and 19 non-DS mentally retarded (MR) persons (26-91 years of age) by using a sandwich enzyme linked immunosorbent assay. A beta40 levels were higher in DS and MR than controls, but were similar between DS and MR groups. A beta42 levels were higher in DS than controls or MR persons. The ratios of A beta42/A beta40 were higher in DS than controls or MR persons. The findings are consistent with those seen in DS brains.

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