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Cat. No.: HY-161873

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PW507

PW507 is a potent, brain-penetrant and selective sigma 1 receptor (S1R) antagonist with a K_i of 7.5 nM for human S1R. PW507 displays a low binding affinity to S2R and hERG. PW507 can be used for the study of painful diabetic neuropathy (PDN).

For research use only. We do not sell to patients.

CAS No.: 2573850-59-4
Formula: C₁₈H₂₇ClN₄
Molecular Weight:334.89

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

PW507 Chemical Structure

CAS No.: 2573850-59-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Sigma Receptor Isoforms :

In Vitro

PW507 binds to the orthosteric site of the human S1R crystal structure and engages in strong interactions with the receptor^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PW507 (20 mg/kg; i.p; twice daily; for 14 days) demonstrates significant efficacy in alleviating mechanical allodynia hyperalgesia^[1].
PW507’s Pharmacokinetic Properties in SD rats Studies^[1].
1.19

plasma PK	IV	PO	IP
dose (mg/kg)	1	25	10
t_max (h)	N/A	1.20	0.25
t_1/2 (h)	0.53	0.69	0.56
C_max (ng/mL)	193	296	671
AUC_0-inf (h*ng/mL)	108	692	552
CL (mL/min/kg)	155	N/A	N/A
ratio (brain/plasma, t = 0.25 h)	N/A	N/A	12
F (%)	100	28	51

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male SD rats injected Streptozotocin (HY-13753; STZ; 60 mg/kg)^[1]
Dosage:

20 mg/kg
Administration:

i.p; twice daily; for 14 days
Result:

Demonstrated significant efficacy in alleviating mechanical allodynia hyperalgesia.

Chemical Information

CAS No. 2573850-59-4
Molecular Weight 334.89
Formula C₁₈H₂₇ClN₄
SMILES

CC(C)(C)C1=CC=C(C2=NC(CN3CCCC3)=NN2C)C=C1.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Youyi Peng, et al. Preclinical Evaluation of Sigma 1 Receptor Antagonists as a Novel Treatment for Painful Diabetic Neuropathy. ACS Pharmacol. Transl. Sci. July 18, 2024.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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PW507

All Sigma Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PW507 Related Classifications

HY-161873 Related Classifications