PSG9 Protein, Human (HEK293, His)
Based on 1 Customer Validation
PSG9 Protein, Human (HEK293, His) is the recombinant human-derived PSG9 protein, expressed by HEK293, with C-6*His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
PSG9 Protein, Human (HEK293, His) is the recombinant human-derived PSG9 protein, expressed by HEK293, with C-6*His labeled tag.
Background
Pregnant-specific beta-1-glycoprotein 9 is a member of the Pregnancy-specific glycoprotein family and is secreted by placental syncytial trophoblastic cells from the formation of the blastocyst syncytium to term. PSG9 stimulates the increase of FoxP3+ regulatory T cells through the TGF-β1 pathway. PSG is considered to be a pro-angiogenic factor that induces endodermal duct formation and VEGFA secretion in different cell types, promotes angiogenesis by stimulating VEGFA production, and is associated with poor prognosis in hepatocellular carcinoma. PSG9 is involved in Wnt signaling and is dysregulated during colorectal cancer development[1][2][3].
MCE Validation Data
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Purity - SDS-PAGE
Purity - SDS-PAGE
Technical Parameters
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Species Human
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Source HEK293
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Tag C-6*His
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Accession
AAH20759.1 (E35-S426)
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Molecular Construction
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N-term
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PSG9 (E35-S426)
Accession # AAH20759.1 -
6*His
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C-term
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Protein Length
Full Length of Pregnancy-specific beta-1-glycoprotein 9 Chain
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Synonyms
PSG9; PS34; Prev. PSG11; Pregnancy-Specific Glycoprotein 11; PSGII; Pregnancy-Specific Glycoprotein 7; Pregnancy-Specific Beta-1-Glycoprotein 9; Pregnancy-Specific Glycoprotein 9; Pregnancy-Specific Beta-1 Glycoprotein B; PS-Beta-G-11; PS-Beta-G-9; PSG9 P
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AA Sequence
EVTIEAQPPKVSEGKDVLLLVHNLPQNLPGYFWYKGEMTDLYHYIISYIVDGKIIIYGPAYSGRETVYSNASLLIQNVTRKDAGTYTLHIIKRGDETREEIRHFTFTLYLETPKPYISSSNLNPREAMEAVRLICDPETLDASYLWWMNGQSLPVTHRLQLSKTNRTLYLFGVTKYIAGPYECEIRNPVSASRSDPVTLNLLPKLPIPYITINNLNPRENKDVLAFTCEPKSENYTYIWWLNGQSLPVSPGVKRPIENRILILPSVTRNETGPYQCEIQDRYGGLRSNPVILNVLYGPDLPRIYPSFTYYRSGENLDLSCFTESNPPAEYFWTINGKFQQSGQKLFIPQITRNHSGLYACSVHNSATGKEISKSMTVKVSGPCHGDLTESQS
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Predicted Molecular Mass
45.6 kDa
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Molecular Weight
Approximately 65 kDa, based on SDS-PAGE under reducing conditions.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
Supplied as a 0.22 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (237 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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