1. Vitamin D Related/Nuclear Receptor
  2. Androgen Receptor
  3. RLA-4842

RLA-4842 is an iron activator containing anti-androgen. RLA-4842 has anti-proliferative activity on metastatic castration-resistant prostate cancer (mCRPC) cell line.

For research use only. We do not sell to patients.

RLA-4842 Chemical Structure

RLA-4842 Chemical Structure

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Description

RLA-4842 is an iron activator containing anti-androgen. RLA-4842 has anti-proliferative activity on metastatic castration-resistant prostate cancer (mCRPC) cell line[1].

In Vitro

RLA-4842 (compound 9) (0-25 µM; 10 min) inhibits LNCaP-AR cells proliferation with concentration-dependent manner[1].
RLA-4842 (5 µM; 0-6 d) shows inhibitory for VCaP, PC3, LNCaP and C4-2B cells proliferation[1].
RLA-4842 (5 µM; 24 h) down-regulates the expression level of KLK-2 and KLK-3 in LNCaP cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: VCaP, PC3, LNCaP and C4-2B cells.
Concentration: 0, 0.1, 0.5, 1, 5, 10, 20 or 25 µM.
Incubation Time: 0-6 d.
Result: Showed antiproliferative effect.
Molecular Weight

837.90

Formula

C42H46F3N5O8S

SMILES

CN(C(OC1=CC=C(C=C1)N2C(N(C(C23CCC3)=O)C4=CC(C(F)(F)F)=C(C=C4)C#N)=S)=O)CCN(C(O[C@@H]5CCC[C@@]6(OOC7(C8CC9CC(CC7C9)C8)O6)C5)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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RLA-4842 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
RLA-4842
Cat. No.:
HY-152512
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