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製品番号: HY-134146

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ROCK2-IN-20

ROCK2-IN-20 is a selective ROCK2 inhibitor with an IC₅₀ value of 12 nM. ROCK2-IN-20 can be used for research on multiple sclerosis, pulmonary arterial hypertension, and glaucoma.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1219722-56-1
分子式: C₁₉H₂₀N₄O₂
分子量:336.40

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

ROCK2-IN-20 構造式

CAS 番号: 1219722-56-1

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

ROCK2-IN-20 is a selective ROCK2 inhibitor with an IC₅₀ value of 12 nM. ROCK2-IN-20 can be used for research on multiple sclerosis, pulmonary arterial hypertension, and glaucoma^[1].

IC₅₀ & Target

^[1]

ROCK2

12 nM (IC₅₀)

PKA

610 nM (IC₅₀)

ROCK アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A7R5	IC₅₀	59 nM Compound: 12o	Inhibition of ROCK-mediated myosin light chain bisphosphorylation in rat A7R5 cells after 1 hr by fluorescence assay in presence of L-alpha-lysophosphatidic acid Inhibition of ROCK-mediated myosin light chain bisphosphorylation in rat A7R5 cells after 1 hr by fluorescence assay in presence of L-alpha-lysophosphatidic acid	[PMID: 23570561]

体外実験

ROCK2-IN-20 (Compound 56) inhibits ROCK2 in the STK2 biochemical assay with an IC₅₀ of 12 nM, and shows an IC₅₀ of 610 nM against PKA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Cardiovascular Diseases

化学情報

CAS 番号 1219722-56-1
分子量 336.40
分子式 C₁₉H₂₀N₄O₂
SMILES

O=C(NC=1C=CC(=CC1)C=2C=NNC2)N(CC=3C=CC=CC3)CCO
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (275 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Mei D, et al. Discovery of potent and selective urea-based ROCK inhibitors: Exploring the inhibitor's potency and ROCK2/PKA selectivity by 3D-QSAR, molecular docking and molecular dynamics simulations. Bioorganic & medicinal chemistry. 2015 May 15;23(10):2505-17. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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