country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-184876

Copy Link Print Information

RORγt inverse agonist 38

RORγt inverse agonist 38 (C102) is a RORγt inverse agonist. RORγt inverse agonist 38 can be used for the research of psoriasis, autoimmune thyroiditis, inflammatory bowel disease, cancer, and other conditions.

For research use only. We do not sell to patients.

CAS No.: 2891663-21-9
Formula: C₂₃H₁₅Cl₂F₄N₃O₂
Molecular Weight:512.28

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

RORγt inverse agonist 38 Chemical Structure

CAS No.: 2891663-21-9

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

RORγt

All ROR Isoforms :

In Vitro

RORγt inverse agonist 38 (C102) is a RORγ/RORγt inverse agonist. The potency of its RORγt inverse agonistic activity varies among compound variants, with an IC₅₀ range of <10 nM to 100 nM-<1 μM^[1].
The intrinsic clearance of RORγt inverse agonist 38 (60 min) in rat and human liver microsomes is 32.3 and 11.2 μL/min/mg protein, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2891663-21-9
Molecular Weight 512.28
Formula C₂₃H₁₅Cl₂F₄N₃O₂
SMILES

FC1=CC=CC(Cl)=C1C2=NOC(C3=C(C(F)(F)F)N(C4=CC(Cl)=CC=C4)N=C3)=C2COC5CC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gege C, et al. Deuterated RORgamma/RORgammat inverse agonists. WO 2023/198873 A1. World Intellectual Property Organization. 2023-10-19.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

RORγt inverse agonist 38

All ROR Isoforms