2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. RS-102221 hydrochloride

RS-102221 hydrochloride is a selective 5-HT2C receptor antagonist (Ki=10 nM). RS-102221 hydrochloride shows nearly 100-fold selectivity for the 5-HT2C receptor as compared to the 5-HT2A and 5-HT2B receptors. RS-102221 hydrochloride can promote the differentiation of new nerve cells. RS-102221 hydrochloride increases food-intake and weight-gain in rats.

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RS-102221 hydrochloride Chemical Structure

RS-102221 hydrochloride Chemical Structure

CAS No. : 187397-18-8

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Based on 1 publication(s) in Google Scholar

Other Forms of RS-102221 hydrochloride:

RS-102221 hydrochloride Related Antibodies

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Description

RS-102221 hydrochloride is a selective 5-HT2C receptor antagonist (Ki=10 nM). RS-102221 hydrochloride shows nearly 100-fold selectivity for the 5-HT2C receptor as compared to the 5-HT2A and 5-HT2B receptors. RS-102221 hydrochloride can promote the differentiation of new nerve cells. RS-102221 hydrochloride increases food-intake and weight-gain in rats[1][2].

IC50 & Target[1]

5-HT2C Receptor

10 nM (Ki)

5-HT2A Receptor

 

5-HT2B Receptor

 

In Vitro

RS-102221 hydrochloride (0.3-300nM; 24 h) promotes the differentiation of adult hippocampal neural precursor cells (ahNPCs) and significantly increases the percentage of MAP-2+ cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RS-102221 hydrochloride Related Antibodies

Cell Differentiation Assay[1]

Cell Line: Mouse adult hippocampal neural progenitor cells (ahNPCs)
Concentration: 0.3, 1, 10, 30, 100, and 300 nM
Incubation Time: 24 hours
Result: Significantly increases the percentage of MAP-2+ cells at 10 nM.
In Vivo

RS-102221 hydrochloride (2 mg/kg; i.p.; once daily for 14 d) increases food-intake and weight-gain in rats[2].
RS-102221 hydrochloride (2 mg/kg; i.p.; single dose), combined with the 3,4-Methylenedioxy-N-methamphetamine (MDMA or 'ecstasy'), suppresses the MDMA-induced hypophagia for the first 1 h period, and also suppresses MDMA-induced hyperlocomotion in mice[3].
RS-102221 hydrochloride (2 mg/kg; i.p.; single dose) can reduce anxiety and reduce the amplitude of startle reflex in mice in light and dark test[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

649.08

Formula

C27H32ClF3N4O7S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=C(C(F)(F)F)C=C1)(NC2=CC(C(CCCCN(CC3)CCC3(NC(N4)=O)C4=O)=O)=C(OC)C=C2OC)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (192.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5406 mL 7.7032 mL 15.4064 mL
5 mM 0.3081 mL 1.5406 mL 3.0813 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5406 mL 7.7032 mL 15.4064 mL 38.5161 mL
5 mM 0.3081 mL 1.5406 mL 3.0813 mL 7.7032 mL
10 mM 0.1541 mL 0.7703 mL 1.5406 mL 3.8516 mL
15 mM 0.1027 mL 0.5135 mL 1.0271 mL 2.5677 mL
20 mM 0.0770 mL 0.3852 mL 0.7703 mL 1.9258 mL
25 mM 0.0616 mL 0.3081 mL 0.6163 mL 1.5406 mL
30 mM 0.0514 mL 0.2568 mL 0.5135 mL 1.2839 mL
40 mM 0.0385 mL 0.1926 mL 0.3852 mL 0.9629 mL
50 mM 0.0308 mL 0.1541 mL 0.3081 mL 0.7703 mL
60 mM 0.0257 mL 0.1284 mL 0.2568 mL 0.6419 mL
80 mM 0.0193 mL 0.0963 mL 0.1926 mL 0.4815 mL
100 mM 0.0154 mL 0.0770 mL 0.1541 mL 0.3852 mL
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RS-102221 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RS-102221187397-18-8RS102221RS 1022215-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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