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Cat. No.: HY-123313

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S-8660

S-8660 is an orally active, selective inhibitor of dihydroorotate dehydrogenase (DHODH). As an antiproliferative prodrug and an analog of Brequinar (HY-108325), S-8660 exhibits immunosuppressive activity. Its effect on prolonging cardiac allograft survival is enhanced when used in combination with Cyclosporin A (HY-B0579). S-8660 can be used in studies of cardiac transplant rejection.

For research use only. We do not sell to patients.

CAS No.: 96201-52-4
Formula: C₂₃H₁₆ClNO₂
Molecular Weight:373.83

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

S-8660 Chemical Structure

CAS No.: 96201-52-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
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Biological Activity

Description

In Vitro

S-8660 selectively inhibits mitochondrial dihydroorotate dehydrogenase, disrupting de novo pyrimidine synthesis in a cell-free biochemical system^[1].
S-8660 suppresses human mixed-lymphocyte responses in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

S-8660 (5-20 mg/kg; p.o.; once daily; starting 2 days pre-transplant for up to 30 days post-transplant) prolongs cardiac allograft survival in rats in a dose-dependent fashion, with a tapered dose regimen achieving a median survival time of 32 days^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ACI (RT1a) donors; Lewis (RT1¹) recipients^[1]
Dosage:

5 mg/kg; 20 mg/kg
Administration:

p.o.; once daily; starting 2 days pre-transplant for up to 30 days post-transplant
Result:

Extended cardiac allograft survival in a dose-dependent manner.
Achieved a median graft survival time of 32 days with the tapered dose regimen, compared to control median survival of 7 days.

Chemical Information

CAS No. 96201-52-4
Molecular Weight 373.83
Formula C₂₃H₁₆ClNO₂
SMILES

O=C(O)C1=C(C(C2=CC=C(C=C2)C3=CC=CC=C3)=NC4=CC=CC(Cl)=C14)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Cramer DV, et al. Inhibition of the pyrimidine biosynthetic pathway with S-8660, an analogue of brequinar sodium, prolongs cardiac allograft survival in rats. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 1993;12(1 Pt 1):140-6.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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