SDH-IN-56
SDH-IN-56 is a succinate dehydrogenase (SDH) inhibitor that blocks succinate oxidation and fungal energy metabolism. SDH-IN-56 disrupts fungal cell membrane integrity and increases membrane permeability, leading to leakage of intracellular contents and a decrease in extracellular pH. SDH-IN-56 induces intracellular reactive oxygen species (ROS) accumulation and loss of mitochondrial membrane potential. SDH-IN-56 can be used for research on fungal infections.
For research use only. We do not sell to patients.
- Formula: C18H19BrN4O2
- Molecular Weight:403.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
SDH-IN-56 (0.18-6.25 mg/L) inhibits the colony expansion of M. fructicola and B. cinerea in a concentration-dependent manner, with almost complete inhibition at 6.25 mg/L[1].
SDH-IN-56 (50-200 mg/L) exhibits protective activity and post-inoculation activity against peach fruit infected with M. fructicola; on day 6, the protective inhibition rate at 200 mg/L is 77.6%, and the post-inoculation inhibition rate is 69.1%[1].
SDH-IN-56 (0.196-0.49 mg/L) disrupts the mycelial morphology and cellular ultrastructure of M. fructicola[1].
SDH-IN-56 (1-10 mg/L; 30-120 min) impairs the membrane integrity of M. fructicola, increases permeability, and leads to the leakage of electrolytes, nucleic acids, and proteins[1].
SDH-IN-56 (0.196-0.49 mg/L; 3 d) disrupts the cell membrane integrity of M. fructicola in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 403.27
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Formula C18H19BrN4O2
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SMILES
C=C([C@@H]1CC=C(CC1)C2=NN=C(O2)C(NNC3=CC=C(C=C3)Br)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SDH-IN-56 Related Classifications
HY-190728 Related Classifications
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Keywords
- SDH-IN-56
- Succinate Dehydrogenase
- Fungal
- Reactive Oxygen Species (ROS)
- Botrytis cinerea
- Monilinia fructicola
- cell membrane integrity
- fungal energy metabolism
- membrane permeability
- mitochondrial membrane potential
- peach brown rot
- reactive oxygen species
- succinate dehydrogenase
- succinate oxidation
- Inhibitor
- inhibitor
- inhibit