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Cat. No.: HY-177023

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Ap5dT

Ap5dT is a cytosolic thymidine kinase and mitochondrial enzyme inhibitor with K_is of 0.12 μM and 0.50 μM, respectively. Ap5dT can be used for the study of acute myelocytic leukemia.

For research use only. We do not sell to patients.

CAS No.: 103137-88-8
Formula: C₂₀H₃₀N₇O₂₃P₅
Molecular Weight:891.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Ap5dT Chemical Structure

CAS No.: 103137-88-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Ap5dT is a cytosolic thymidine kinase and mitochondrial enzyme inhibitor with K_is of 0.12 μM and 0.50 μM, respectively. Ap5dT can be used for the study of acute myelocytic leukemia^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
L1210	IC₅₀	14 μM Compound: Ap5T	Concentration required to reduce Ribonucleotide reductase rate by 50% in L1210 cells Concentration required to reduce Ribonucleotide reductase rate by 50% in L1210 cells	[PMID: 2838631]
L1210	IC₅₀	2.5 μM Compound: Ap5T	Concentration required to reduce thymidine kinase rate by 50% in L1210 cells Concentration required to reduce thymidine kinase rate by 50% in L1210 cells	[PMID: 2838631]

Chemical Information

CAS No. 103137-88-8
Molecular Weight 891.35
Formula C₂₀H₃₀N₇O₂₃P₅
SMILES

O[C@@H]1[C@H](O)[C@@H](COP(OP(OP(OP(OP(OC[C@@H](O2)[C@@H](O)C[C@@H]2N3C(NC(C(C)=C3)=O)=O)(O)=O)(O)=O)(O)=O)(O)=O)(O)=O)O[C@H]1N4C5=NC=NC(N)=C5N=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bone R, et al. Inhibition of thymidine kinase by P1-(adenosine-5')-P5-(thymidine-5')-pentaphosphate. J Biol Chem. 1986 May 5;261(13):5731-5. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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