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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3812 Results for "
derived
" in MedChemExpress (MCE) Product Catalog:
Products (3812)
3812 Results for "derived" in MCE Product Catalog:
Cat. No.: HY-L238
2,383 compounds
Mongolian medicine refers to drugs used for disease prevention and treatment under the guidance of Mongolian medical theory. Originating from the vast grasslands and desert regions of northern China, Mongolian medicine developed under specific natural conditions and a nomadic lifestyle, forming a unique theoretical system and treatment methods. It emphasizes the balance between the human body and the natural environment and has demonstrated distinct efficacy in treating digestive system diseases, rheumatism, skin diseases, and various chronic conditions. For example, Mongolian medicine often uses Chinese red date for palpitations and angina pectoris, sea buckthorn to relieve coughs, reduce phlegm, promote blood circulation, and remove blood stasis, and scabious to clear lung heat and treat liver heat diseases. The application of these characteristic Mongolian medicines embodies the profound wisdom of Mongolian medical practice.
With the advancement of modern technology, research on Mongolian medicine continues to deepen. Systematic studies on the chemical composition and pharmacological effects of Mongolian medicines can provide new ideas and methods for modern drug development.
MCE has collected 2,383 characteristic natural products derived from Mongolian medicines, with 400+ plant sources of Mongolian medicine.
Cat. No.: HY-148775
Purity: ≥95.0%
Cat. No.: HY-189364
CAS No.: 88262-44-6
Synonyms: SMC247-9
Target:
Research Areas:
(DL)-3,5-Dimethyltyrosine (SMC247-9) is a selective APOBEC3B inhibitor optimized from SMC247, with an IC50 of 50 pM. (DL)-3,5-Dimethyltyrosine binds to the APOBEC3B protein, reduces intracellular APOBEC3B protein abundance partially through a lysosome-dependent pathway, enhances IL-15 expression in tumor cells, and relieves the suppression of CD8 + T cells by tumor cells in an IL-15-dependent manner. (DL)-3,5-Dimethyltyrosine attenuates tumor- and macrophage-derived chemokine-mediated macrophage chemotaxis and inhibits pathological myeloid inflammatory signaling. (DL)-3,5-Dimethyltyrosine inhibits tumor growth in the immune checkpoint blockade-responsive MC38 syngeneic mouse model and produces synergistic effects with anti-PD-L1 in the immune checkpoint blockade-resistant TC-1 tumor model; it also ameliorates anti-PD-1-exacerbated DSS-induced colitis-like intestinal inflammatory injury. (DL)-3,5-Dimethyltyrosine can be used in research related to tumor immunotherapy .
Cat. No.: HY-P5415
CAS No.: 127134-13-8
Cat. No.: HY-P990186
Cat. No.: HY-P990269
Target:
Research Areas:
Cat. No.: HY-P990270
Target:
Research Areas:
Cat. No.: HY-P990304B
Target:
Research Areas:
Cat. No.: HY-P990304C
Target:
Research Areas:
Cat. No.: HY-W015777R
CAS No.: 105-13-5
Synonyms: P-Methoxy-benzyl alcoho (Standard); (4-Methoxyphenyl)methanol (Standard)
Cat. No.: HY-W020780
CAS No.: 724722-89-8
Synonyms: mPEG5000-Maleimide
Cat. No.: HY-P70384
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GFRA1; GDNFR-Alpha-1; Prev. GDNFRA; Glial Cell Line-derived Neurotrophic Factor Receptor Alpha; RETL1; PI-Linked Cell-Surface Accessory Protein; TRNR1; GPI-Linked Anchor Protein; GDNF Family Receptor Alpha-1; Alternative Protein GFRA1; GFR-ALPHA-1; GDNF Receptor Alpha 1d; GDNFR; GDNF Receptor Alpha 1e; RET1L; GFR-Alpha-1; TGF-Beta-Related Neurotrophic Factor Receptor 1; GFRalpha-1; GDNF Receptor Alpha-1; RHDA4; GDNF Family Receptor Alpha 1; RET Ligand 1
Species:
Human
Source:
HEK293
Cat. No.: HY-D1056A3
Synonyms: LPS, from Escherichia coli (O26:B6)
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.
Cat. No.: HY-P991744
Cat. No.: HY-L939
10855 compounds
The rising prevalence of multidrug-resistant and extensively drug-resistant bacteria, combined with emerging resistance mechanisms and the limitations of existing antibacterial drugs, creates an urgent need for novel antibacterial agents. Antibacterial compound libraries serve as key tools to support antibacterial drug screening and development.
This library features structurally diverse compounds, including small-molecule scaffolds and natural product derivatives, and exhibits diverse antibacterial mechanisms of action. For example, these compounds exert antibacterial effects by disrupting bacterial cell structures, interfering with bacterial metabolic processes, and inhibiting nucleic acid synthesis. The derivation of scaffold structures enhances their activity against drug-resistant bacteria and their selectivity against different types of bacteria. This library can be used for the high-throughput screening of novel antibacterial drug candidates and the identification of potent compounds against drug-resistant and multidrug-resistant bacteria. Additionally, it provides a reference for compound structural modification, enabling further in-depth research on the structure-activity relationships(SARs) of antibacterial drugs. It can also be applied to the exploration of bacterial resistance mechanisms and reversal strategies, as well as the discovery of antibacterial molecules that inhibit efflux pumps and restore drug susceptibility.
The library contains 10855 structurally diverse drug-like compounds. Its core compound sources include analogs of known antifungal active moleculeswith a similarity score of ≥ 0.6. MCE has collected more than 1900 antibacterial molecules. All screened compounds conform to lead-like physicochemical properties, providing valuable support for the research and development of novel antibacterial drugs.
Cat. No.: HY-P704907
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPT; Tau-derived Paired Helical Filament Hexapeptide; Prev. MAPTL; Microtubule-Associated Protein Tau; Prev. DDPAC; Neurofibrillary Tangle Protein; MTBT1; Paired Helical Filament-Tau; PPP1R103; MGC138549; Tau-PHF6; FLJ31424; FTDP-17; PHF-Tau; Tau-40; Microtubule-Associated Protein Tau, Isoform 4; MTBT2; Mutant Microtubule-Associated Protein Tau; PPND; Microtubule-Associated Protein; MSTD; FTD1; Tau; TAU; G Protein Beta1/Gamma2 Subunit-Interacting Factor 1; Microtubule Associated Protein Tau; Protein Phosphatase 1, Regulatory Subunit 103
Species:
Human
Source:
E. coli
Cat. No.: HY-P704910
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPT; Tau-derived Paired Helical Filament Hexapeptide; Prev. MAPTL; Microtubule-Associated Protein Tau; Prev. DDPAC; Neurofibrillary Tangle Protein; MTBT1; Paired Helical Filament-Tau; PPP1R103; MGC138549; Tau-PHF6; FLJ31424; FTDP-17; PHF-Tau; Tau-40; Microtubule-Associated Protein Tau, Isoform 4; MTBT2; Mutant Microtubule-Associated Protein Tau; PPND; Microtubule-Associated Protein; MSTD; FTD1; Tau; TAU; G Protein Beta1/Gamma2 Subunit-Interacting Factor 1; Microtubule Associated Protein Tau; Protein Phosphatase 1, Regulatory Subunit 103
Species:
Human
Source:
E. coli
Cat. No.: HY-P706282
Purity: ≥ 95%, as determined by HPLC.
Synonyms: ¹⁵N-Insulin-like growth factor 2; ¹⁵N-IGF-II; ¹⁵N-Somatomedin-A; ¹⁵N-Skeletal Growth Factor; ¹⁵N-SGF; IGF2; Insulin-Like Growth Factor 2 (Somatomedin A); Prev. C11orf43; Insulin-Like Growth Factor Type 2; Insulin-Like Growth Factor 2; Somatomedin A; IGF-II; Somatomedin-A; Insulin-Like Growth Factor II; PP9974; T3M-11-derived Growth Factor; IGF-2; FLJ44734; GRDF; Preptin; SRS3; Insulin Like Growth Factor 2; Chromosome 11 Open Reading Frame 43
Species:
Human
Source:
E. coli
Cat. No.: HY-P73064
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: FLT1; Tyrosine-Protein Kinase FRT; Prev. FLT; FLT-1; Vascular Endothelial Growth Factor Receptor 1; Vascular Endothelial Growth Factor Receptor 1 Variant; VEGFR1; Platelet-derived Growth Factor Receptor-Like Protein; Vascular Permeability Factor Receptor; Fms-Related Tyrosine Kinase 1; Tyrosine-Protein Kinase Receptor FLT; Soluble FLT1 Variant E15a; Fms-Like Tyrosine Kinase 1; P19FLT1; Fms-Related Tyrosine Kinase 1 (Vascular Endothelial Growth Factor/Vascular Permeability Factor Receptor); P28FLT1; Fms Related Tyrosine Kinase 1; FRT; Fms Related Receptor Tyrosine Kinase 1; VEGFR-1
Species:
Human
Source:
HEK293
Cat. No.: HY-P702691
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: KIT; C-Kit Protooncogene; Prev. PBT; Platelet-derived Growth Factor Receptor-Like Protein; Mast/Stem Cell Growth Factor Receptor Kit; Mast/Stem Cell Growth Factor Receptor Variant; SCFR; Proto-Oncogene Tyrosine-Protein Kinase Kit; V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog; Mast/Stem Cell Growth Factor Receptor; Tyrosine-Protein Kinase Kit; Receptor Protein-Tyrosine Kinase; Proto-Oncogene C-Kit; Alternative Protein KIT; C-Kit; Piebald Trait; CD117; CD117 Antigen; V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene-Like Protein; KIT Protein; Piebald Trait Protein; MASTC; KIT Proto-Oncogene, Receptor Tyrosine Kinase; P145 C-Kit
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
