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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
53 Results for "
APJ
" in MedChemExpress (MCE) Product Catalog:
Products (53)
53 Results for "APJ" in MCE Product Catalog:
Cat. No.: HY-175818
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APJ antagonist-1 is an apelin receptor (APJ) antagonist. APJ antagonist-1 shows strong β-arrestin inhibition with an IC50 of 3.1 μM. APJ antagonist-1 selectively inhibits APJ-overexpressing cancer cells and suppresses apelin-induced endothelial cell migration. APJ antagonist-1exhibits high metabolic stability. APJ antagonist-1 can used for the studies of ovarian cancer and tumor angiogenesis .
Cat. No.: HY-P1064A
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Cat. No.: HY-126293
CAS No.: 2227512-85-6
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Apelin agonist 1 is an oral selective apelin agonist AM-2995, a agonist of the APJ (APLNR, angiotensin receptor like-1) receptor, may be used in the treatment of cardiovascular conditions. Apelin agonist 1 is extracted from patent WO 2018097944 (210.0), Example 210.0 .
Cat. No.: HY-160076
CAS No.: 2049973-39-7
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APJ receptor agonist 8 (compound 99) is an agonist of APJ receptor. APJ receptor agonist 8 increases the load independent cardiac contractility of isolated perfused rat hearts .
Cat. No.: HY-139486
CAS No.: 2049973-02-4
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AM-8123 is an orally active and potent APJ agonist. AM-8123 inhibits Forskolin-stimulated cAMP production and promotes Gα protein activation. AM-8123 can be used for the research of cardiovascular disease .
Cat. No.: HY-P7061
CAS No.: 143413-49-4
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Cat. No.: HY-133036
CAS No.: 2287153-38-0
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APJ receptor agonist 1, a biphenyl acid derivative, is a potent APJ receptor (APJ-R) agonist (EC50s 0.093 and 0.12 nM for human and rat APJ-R, respectively). APJ receptor agonist 1 displays in vitro potency to apelin-13, the endogenous peptidic ligand for the APJ receptor. APJ receptor agonist 1 has the potential for the research of heart failure .
Cat. No.: HY-145285
CAS No.: 2135514-20-2
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APJ receptor agonist 5 (compound 3) is a potent and orally active agonist of apelin receptor (APJ) with an EC50 of 0.4 nM. APJ receptor agonist 5 displays excellent pharmacokinetic profiles in the rodent heart failure (HF) model. APJ receptor agonist 5 also shows an acceptable safety profile in preclinical toxicology studies. APJ receptor agonist 5 leads to improved cardiac function and can be used for researching the HF disease .
Cat. No.: HY-139876
CAS No.: 2759159-56-1
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APJ receptor agonist 3 is a potent and orally active APJ receptor agonist with an EC50 value of 0.027 nM.
Cat. No.: HY-P3346
CAS No.: 2891469-80-8
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NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) (compound 39) is a potent APJ agonist, with a Ki of 0.6 nM. NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) can activate Gαi1 (EC50=0.8 nM) and recruit β-arrestin2 (EC50=31 nM). NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) exhibits prolonged cardiac effects .
Cat. No.: HY-169752
CAS No.: 2135515-67-0
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APJ receptor agonist 11 (Ex 174) is a APJ receptor agonist with IC50 values ranging from 0.01 nM to 10 nM. APJ receptor agonist 11 can be used in the study of cardiovascular diseases .
Cat. No.: HY-145284
CAS No.: 2762567-70-2
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APJ receptor agonist 4 is a potent and orally active agonist of apelin receptor (APJ) with EC50 and Ki of 0.06 nM and 0.07 nM respectively. APJ receptor agonist 4 displays excellent pharmacokinetic profiles in the rodent heart failure (HF) model. APJ receptor agonist 4 also shows an acceptable safety profile in preclinical toxicology studies. APJ receptor agonist 4 leads to improved cardiac function and can be used for researching the HF disease .
Cat. No.: HY-P1066A
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Cat. No.: HY-P3162
CAS No.: 568565-11-7
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Cat. No.: HY-P3347
CAS No.: 2891469-81-9
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Cat. No.: HY-170419A
CAS No.: 2415197-87-2
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APJ receptor agonist 10 free base is an agonist of the APJ Receptor. APJ receptor agonist 10 free base can be used for research on pulmonary arterial hypertension .
Cat. No.: HY-RS00825
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Aplnr Rat Pre-designed siRNA Set A contains three designed siRNAs for Aplnr gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS00824
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Aplnr Mouse Pre-designed siRNA Set A contains three designed siRNAs for Aplnr gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS00823
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APLNR Human Pre-designed siRNA Set A contains three designed siRNAs for APLNR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P1065A
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
