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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
253 Results for "
CES
" in MedChemExpress (MCE) Product Catalog:
Products (253)
253 Results for "CES" in MCE Product Catalog:
Cat. No.: HY-170938
Research Areas:
AChE-IN-82 (compound 49) is an acetylcholinesterase (AChE) inhibitor. AChE-IN-82 inhibits eeAChE, eqBChE, hMAO-A, hMAO-B, and BACE-1 with IC50s of 0.072, 9.81, 14.52, 0.024, 2.42 μM, respectively. AChE-IN-82 inhibits COX-1, COX-2 and 5-LOX with IC50s of 60.41, 0.187, 0.18 μM, respectively. AChE-IN-82 shows an excellent neuroprotective effect by significantly reducing oxidative stress induced by H2 O2 .
Cat. No.: HY-176841
CAS No.: 648894-93-3
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Carboxylesterase-IN-5 (Compound 2e) is an irreversible and competitive Carboxylesterase (CES) inhibitor with an IC50 of 21.7 nM for porcine liver CES. Carboxylesterase-IN-5 can be used for hypocholesterolemia research .
Cat. No.: HY-19173
CAS No.: 150493-09-7
Synonyms: MDL 201,404YA
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CE-1037 (MDL 201,404YA) is a selective inhibitor of human neutrophil elastase (HNE) (Ki: 0.45 nM). CE-1037 prevents the pulmonary hemorrhage induced by intratracheal instillation of HNE. CE-1037 can be used for research of pulmonary diseases, such as COPD .
Cat. No.: HY-113477
CAS No.: 77715-45-8
Synonyms: Cholesteryl 11,14-eicosadienoate
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CE(20:2(6Z,9Z)) (Cholesteryl 11,14-eicosadienoate) is an ester product.
Cat. No.: HY-171631
CAS No.: 2133842-85-8
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5'-O-DMTr-Nap-dU-3'-CE Phosphoramidite is a phosphoramidite monomer used in nucleic acid synthesis, such as oligonucleotides.
Cat. No.: HY-113086
CAS No.: 16711-66-3
Synonyms: 16:1(9Z) CE; 16:1(9Z) Cholesterol ester; Cholesterol Palmitoleate
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CE(16:1(9Z)) (16:1(9Z) CE) is a cholesterol ester. Plasma levels of cholesteryl palmitoleate are increased in ApoE -/- mice exposed to cigarette smoke and in pediatric patients with biliary atresia. Cholesteryl palmitoleate has been used as a standard for the identification of cholesterol esters in human meibomian gland secretions.
Cat. No.: HY-P991565
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Cat. No.: HY-11074
CAS No.: 870615-40-0
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CE-326597 is a small molecule agonist of the cholecystokinin A receptor (CCKAR). CE-326597 occupies only the lower half of the TMD pocket and cannot mimic the crucial interaction between CCK-8 and ECL1-3. CE-326597 can be used to study metabolic diseases and gastrointestinal dysfunction .
Cat. No.: HY-119337
CAS No.: 208840-22-6
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CE-2072 is an inhibitor of serine proteases neutrophil elastase and proteinase-3. CE-2072 inhibits HIV-1 production and p24 production in response to IL-18 or NaCl in infected U1 monocytic cells, reduces virus replication in infected peripheral blood mononuclear cells and blocks infection of permissive HeLa cells. CE-2072 suppresses activation of the HIV-1-inducing transcription factor NF-kB in U1 cells. CE-2072 is promising for research of HIV-1-related disease .
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CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50s of 4.7 and 1 nM.
Cat. No.: HY-W714969A
CAS No.: 1393524-83-8
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BCN-CE-phosphoramidite is an oligonucleotide modifier containing a BCN strained cyclooctyne structure. BCN-CE-phosphoramidite possesses bioorthogonal reactivity and bioconjugation capability .
Cat. No.: HY-E70375
CAS No.: 153302-42-2
Synonyms: Fructosyl-peptide: oxygen oxidoreductase
Fructosyl-peptide oxidase (FPOX-CE) (Fructosyl-peptide: oxygen oxidoreductase) is an enzyme that catalyzes the oxidation of glycopeptides. Fructosyl-peptide oxidase (FPOX-CE) shows high activity against small molecule glycated peptides, but no activity is detected against the glycated hexapeptide standard fVHLTPE used in the study. Fructosyl-peptide oxidase (FPOX-CE) can be used in the study of diabetes monitoring .
Cat. No.: HY-P11030
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Cat. No.: HY-155755
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CES2A-IN-1 (compound 20w) is a potent CES2A inhibitor with an IC50 value of 1.6 nM for human CES2A. CES2A-IN-1, a bysspectin A derivative, shows an approximately 1000-fold improvement over the lead compound bysspectin A .
Cat. No.: HY-173267
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CES2A-IN-2 (compound 14n) is an orally active, highly specific, irreversible and covalent CES2A inhibitor with an IC50 of 0.04 nM for human CES2A. CES2A-IN-2 covalently binds to CES2A by specifically targeting the catalytic serine residue (Ser-228). CES2A-IN-2 can significantly ameliorate Irinotecan-triggered gut toxicity (ITGT) without diminishing the anti-tumor effects of Irinotecan (HY-16562) in tumor-bearing mice .
Cat. No.: HY-D2285
CAS No.: 2956672-93-6
Cat. No.: HY-176465
CAS No.: 3037959-47-7
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CES2A-IN-3 (Compound 9d) is a potent serine-targeting covalent human carboxylesterase 2A (hCES2A) inhibitor with an IC50 value of 0.12 nM. CES2A-IN-3 is promising for research of diarrhea and ulcerative colitis .
Cat. No.: HY-168516
CAS No.: 3004676-87-0
FXR/CES2 modulator 1 (compound LE-77) is a doul modulator that activates FXR and inhibits CES2. FXR/CES2 modulator 1 effectively mitigates the intestinal toxicity of irinotecan .
Cat. No.: HY-RS02543
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CES1 Human Pre-designed siRNA Set A contains three designed siRNAs for CES1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS02544
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CES2 Human Pre-designed siRNA Set A contains three designed siRNAs for CES2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
