208840-22-6
Chemical Structure
CE-2072
- CAS No.: 208840-22-6
- Formula:C33H41N5O6
- Molecular Weight:603.71
IUPAC Name: benzyl ((S)-3-methyl-1-((S)-2-(((S)-3-methyl-1-(5-(3-methylbenzyl)-1,3,4-oxadiazol-2-yl)-1-oxobutan-2-yl)carbamoyl)pyrrolidin-1-yl)-1-oxobutan-2-yl)carbamate
InChIKey: FPGAGACTKJTPFT-MYKRZTLLSA-N
SMILES: O=C([C@H]1N(CCC1)C([C@@H](NC(OCC2=CC=CC=C2)=O)C(C)C)=O)N[C@@H](C(C)C)C(C3=NN=C(O3)CC4=CC=CC(C)=C4)=O
Biological Activity: CE-2072 is an inhibitor of serine proteases neutrophil elastase and proteinase-3. CE-2072 inhibits HIV-1 production and p24 production in response to IL-18 or NaCl in infected U1 monocytic cells, reduces virus replication in infected peripheral blood mononuclear cells and blocks infection of permissive HeLa cells. CE-2072 suppresses activation of the HIV-1-inducing transcription factor NF-kB in U1 cells. CE-2072 is promising for research of HIV-1-related disease[1].
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CE-2072 | CE-2072 is an inhibitor of serine proteases neutrophil elastase and proteinase-3. CE-2072 inhibits HIV-1 production and p24 production in response to IL-18 or NaCl in infected U1 monocytic cells, reduces virus replication in infected peripheral blood mononuclear cells and blocks infection of permissive HeLa cells. CE-2072 suppresses activation of the HIV-1-inducing transcription factor NF-kB in U1 cells. CE-2072 is promising for research of HIV-1-related disease. | |||||||||||||||||||||
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Keywords
