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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
37 Results for "
Clostridium difficile
" in MedChemExpress (MCE) Product Catalog:
Products (37)
37 Results for "Clostridium difficile" in MCE Product Catalog:
Cat. No.: HY-17580R
CAS No.: 873857-62-6
Synonyms: OPT-80 (Standard); PAR-101 (Standard)
Cat. No.: HY-159955
CAS No.: 931411-93-7
DC-159a is an 8-methoxyfluoroquinolone with broad-spectrum antimicrobial activity, especially against Gram-positive pathogens. DC-159a against Peptostreptococcus, Clostridium difficile, and Bacteroides fragilis with MIC90 values of 0.5, 4, and 2 μg/mL, respectively .
Cat. No.: HY-N12228
CAS No.: 114451-31-9
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Cat. No.: HY-B0975AR
CAS No.: 87-08-1
Synonyms: Phenoxymethylpenicillin (Standard)
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Penicillin V (Standard) is the analytical standard of Penicillin V. This product is intended for research and analytical applications. Penicillin V (Phenoxymethylpenicillin) is a potent and orally active antibiotic. Penicillin V shows antibacterial activity for Streptococci, Clostridium difficile and staphylococcus aureus. Penicillin V has the potential for the research of otitis, sinusitis, pharyngitis and tonsillitis [4].
Cat. No.: HY-105099R
CAS No.: 129791-92-0
Synonyms: KRM-1648 (Standard); ABI-1648 (Standard)
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Rifalazil (Standard) is the analytical standard of Rifalazil. This product is intended for research and analytical applications. Rifalazil (KRM-1648; ABI-1648), a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polymerase[1]. Rifalazil (KRM-1648; ABI-1648) is an antibiotic, exhibits high potency against mycobacteria, gram-positive bacteria, Helicobacter pylori, C. pneumoniae and C. trachomatis with MIC values from 0.00025 to 0.0025 μg/ml[3]. Rifalazil (KRM-1648; ABI-1648) has the potential for the treatment of Chlamydia infection, Clostridium difficile associated diarrhea (CDAD), and tuberculosis (TB)[2].
Cat. No.: HY-100436R
CAS No.: 1025097-10-2
Synonyms: ACT-179811 (Standard)
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Cadazolid (Standard) is the analytical standard of Cadazolid. This product is intended for research and analytical applications. Cadazolid (ACT-179811) is a new oxazolidinone antibiotic with potent activity against Clostridium difficile.
Cat. No.: HY-128357A
CAS No.: 1275582-98-3
Synonyms: ACX-362E hydrochloride; GLS-362E hydrochloride
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Ibezapolstat hydrochloride is a first-in-class, orally active DNA polymerase IIIC (pol IIIC) inhibitor, with a Ki of 0.325 μM for the DNA pol IIIC from C. difficile. Ibezapolstat hydrochloride is developed for the research of C. difficile infection(CDI) .
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Betamipron (Standard) is the analytical standard of Betamipron (HY-B1127). This product is intended for research and analytical applications. Betamipron (N-benzoyl-β-alanine) is a carbapenem β-lactam antibiotic with antibacterial activity against most Gram-positive and Gram-negative aerobic and anaerobic bacteria. Betamipron can target and inhibit renal organic anion transporters, alleviate renal injury caused by Cisplatin (HY-17394), without interfering with the biological activity of cisplatin. Betamipron is often used in combination with panipenem, which can attenuate the renal effects induced by panipenem and slightly promote the proliferation of Clostridium difficile in the cecum. Betamipron can be used in studies related to renal injury and bacterial infection .
Cat. No.: HY-138135
CAS No.: 1030825-28-5
Synonyms: Fidaxomicin metabolite OP-1118
OP-1118 (Fidaxomicin metabolite OP-1118) is an orally active dual inhibitor of NF-κB and ERK1/2, with low systemic plasma exposure, no accumulation, and primary excretion via feces. By inhibiting the phosphorylation of NF-κB and ERK1/2 and reducing the expression of pro-inflammatory cytokines, OP-1118 exerts significant anti-inflammatory, cytoprotective, anti-apoptotic and antibacterial activities. In Clostridium difficile infection models, OP-1118 effectively blocks toxin-mediated intestinal inflammation, cell rounding, histological damage and apoptosis, and its protective effect can be reversed by PMA (HY-18739) .
Cat. No.: HY-17580S1
Synonyms: OPT-80-d6; PAR-101-d6
Cat. No.: HY-131476
CAS No.: 1426209-02-0
NAI-802 is a new lantibiotic. NAI-802 can be produced by Actinoplanes sp. NAI-802 shows a significant activity against Gram-positive anaerobic bacteria, such as Clostridium difficile, C. butyricum, C. perfringens and Peptostreptococcus asaccharolyticus with MIC ranges of 0.25-2 μg/mL .
Cat. No.: HY-116880
CAS No.: 2092352-48-0
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DS-2969b is an orally active GyrB inhibitor with antibacterial activity. DS-2969b is is active against Clostridium difficile infection (MIC90: 0.06 μg/mL), which is 2-, 16-, and 32-fold lower than those of Fidaxomicin (HY-17580), Metronidazole (HY-B0318), and Vancomycin (HY-B0671), respectively. DS-2969b inhibits the supercoiling activity of C. difficile DNA gyrase. DS-2969b also exhibits activity against other Gram-positive anaerobes, including strict and facultative anaerobes. DS-2969b is safe and well tolerated in preclinical toxicology studies .
Cat. No.: HY-N21879
CAS No.: 88192-99-8
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Cat. No.: HY-182464
CAS No.: 893603-33-3
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DABMA is a TMEM175 channel activator with a human EC50 of 17.9 μM. DABMA directly increases TMEM175 channel current via interaction with intracellular, transmembrane, or endosomal lumen-associated domains, and does not alter TMEM175 mRNA or protein levels. DABMA delays endolysosomal substrate degradation, modulates endolysosomal trafficking, increases acidic organelle accumulation, induces cholesterol accumulation and altered late endosome morphology. DABMA can be used for the research of coronavirus disease, Clostridium difficile infection, Pseudomonas aeruginosa infection, rabies, and influenza virus infection .
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Benzoyl isothiocyanate is an aromatic isothiocyanate derivative with antibacterial and acaricidal activities. Benzoyl isothiocyanate inhibits the growth of specific oral bacteria, and also serves as an intermediate for the synthesis of heterocyclic compounds such as thiazolidine and quinazoline derivatives. Benzoyl isothiocyanate exhibits acaricidal activity against Dermatophagoides farina (dust mite) and D. pteronyssinus (house dust mite). Benzoyl isothiocyanate can be used in research related to bacterial infection, pest control and organic synthesis .
Cat. No.: HY-181819
CAS No.: 1311163-39-9
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Antibacterial agent 327 (Compound 6f) is an Antibacterial agent. Antibacterial agent 327 potently inhibits the supercoiling activity of Staphylococcus aureus DNA gyrase with an IC50 of 0.28 μM. It also inhibits the ATPase activities of DNA gyrase and Topoisomerase IV, as well as the decatenation activity of Topoisomerase IV (IC50: 0.43 μM, 0.73 μM, and 2.31 μM, respectively). Antibacterial agent 327 potently inhibits Clostridioides difficile and methicillin-resistant Staphylococcus aureus (HY-121544), with an MIC of 0.78 μg/mL for both. Antibacterial agent 327 inhibits Escherichia coli with an MIC50 of 0.78 μg/mL .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
