114451-31-9
Chemical Structure
Phenelfamycin E
- CAS No.: 114451-31-9
- Formula:C65H95NO21
- Molecular Weight:1226.44
InChIKey: UDVVGDCMWCVRCO-WOPDTIQPSA-N
SMILES: CO[C@H]([C@@H]([C@@H](O1)C)O[C@@H]2C[C@H]([C@H]([C@@H](O2)C)O[C@H]3C[C@@H]([C@@H]([C@@H](O3)C)O)OC)OC)C[C@@H]1OC[C@@H]([C@@]4([C@@H]([C@@H](C(C)([C@@H](O4)/C=C/C=C\C)C)O)OC(CC5=CC=CC=C5)=O)O)C(NC/C=C/C=C(C)/[C@@H](OC)[C@H]([C@]6([H])O[C@H]([C@H](C6)O)/C=C/C=C/C=C/C(O)=O)C)=O
Biological Activity: Phenelfamycin E is an elfamycin-type antibiotic. Elfamycin-type antibiotics inhibit protein synthesis by interfering with the function of bacterial elongation factor Tu (F-Tu). Phenelfamycin E has antibacterial activity against Gram-positive anaerobic bacteria, including Clostridioides difficile. Phenelfamycin E can be used in research related to Gram-positive anaerobic bacterial infections[1][2].
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Phenelfamycin E | Phenelfamycin E is an elfamycin-type antibiotic. Elfamycin-type antibiotics inhibit protein synthesis by interfering with the function of bacterial elongation factor Tu (F-Tu). Phenelfamycin E has antibacterial activity against Gram-positive anaerobic bacteria, including Clostridioides difficile. Phenelfamycin E can be used in research related to Gram-positive anaerobic bacterial infections. | |||||||||||||||||||||
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References
- [1]. Brötz E, et al. Phenelfamycins G and H, new elfamycin-type antibiotics produced by Streptomyces albospinus Acta 3619. J Antibiot (Tokyo). 2011 Mar;64(3):257-66. [Content Brief]
- [2]. Swanson RN, et al. Phenelfamycins, a novel complex of elfamycin-type antibiotics. III. Activity in vitro and in a hamster colitis model. J Antibiot (Tokyo). 1989 Jan;42(1):94-101.
