Phenelfamycins G and H, new elfamycin-type antibiotics produced by Streptomyces albospinus Acta 3619

  • J Antibiot (Tokyo). 2011 Mar;64(3):257-66. doi: 10.1038/ja.2010.170.
Elke Brötz  1 ,  Andreas Kulik ,  Sabaratnam Vikineswary ,  Chew-Theng Lim ,  Geok Yuan Annie Tan ,  Heidi Zinecker ,  Johannes F Imhoff ,  Thomas Paululat ,  Hans-Peter Fiedler
Affiliations
  • 1. Institut für Organische Chemie II, Universität Siegen, Siegen, Germany.
PMID: 21285962 DOI: 10.1038/ja.2010.170
Abstract

Phenelfamycins G and H are new members of the family of elfamycin Antibiotics with the basic structure of phenelfamycins E and F, respectively, which are also well known as ganefromycins α and β. Phenelfamycins G and H differ from phenelfamycins E and F by an additional hydroxy group at position C-30, which is not described so far for any of the elfamycin-type Antibiotics. The actinomycete strain that produced phenelfamycins G and H was identified to be Streptomyces albospinus based on its 16S rRNA gene sequence. Phenelfamycins G and H exhibit a narrow Antibacterial spectrum with a pronounced inhibitory activity against Propionibacterium acnes.

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