88 Results for "

Curcumin II-d4

" in MedChemExpress (MCE) Product Catalog:
Products (88)

88 Results for "Curcumin II-d4" in MCE Product Catalog:

製品番号: HY-148598
CAS 番号: 890984-26-6
純度:  98.58%
別名: CUR5-8
Target:  

Apoptosis Autophagy

研究分野:  

Metabolic Disease

Curcumin 5-8 (CUR5-8) is a potent and orally active naturally active curcumin (CUR) analog. Curcumin 5-8 inhibits lipid droplet formation. Curcumin 5-8 increases autophagy and inhibits Apoptosis. Curcumin 5-8 improves insulin resistance and insulin sensitivity .
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製品番号: HY-N0005S
CAS 番号: 1246833-26-0
別名: Diferuloylmethane-d6; Natural Yellow 3-d6; Turmeric yellow-d6
Curcumin-d6 (Diferuloylmethane-d6 ) is deuterium labeled Curcumin (HY-N0005). Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin is a photosensitizer against microorganisms. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.
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製品番号: HY-N2521
CAS 番号: 52328-97-9
別名: FLLL31
Tetramethylcurcumin (FLLL31), derived from curcumin, specifically suppresses the phosphorylation of STAT3 by binding selectively to Janus kinase 2 and the STAT3 Src homology-2 domain. Tetramethylcurcumin exhibits anti-inflammatory and anti-cancer effects .
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製品番号: HY-W002879
CAS 番号: 269409-70-3
4-Hydroxyphenylboronic acid pinacol ester is a ROS-responsive component. 4-Hydroxyphenylboronic acid pinacol ester can structurally modify hyaluronic acid to prepare ROS-responsive intelligent nanocarriers and compound delivery systems. 4-Hydroxyphenylboronic acid pinacol ester endows hyaluronic acid-based nanocarriers with ROS responsiveness, enabling them to rapidly release the encapsulated Curcumin (HY-N0005) in the presence of reactive oxygen species. 4-Hydroxyphenylboronic acid pinacol ester is applicable to research related to periodontitis. 4-Hydroxyphenylboronic acid pinacol ester can also be used for the synthesis of boronic acid-modified resins .
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製品番号: HY-100977
CAS 番号: 160096-59-3
純度:  98.89%
別名: DiMC; CHC 004; Di-O-methylCurcumin
Target:  

NO Synthase NF-κB

研究分野:  

Inflammation/Immunology

Dimethoxycurcumin is a derivative of curcumin that has anti-inflammatory and antioxidant activities .
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製品番号: HY-137315
CAS 番号: 1462868-88-7
純度:  99.01%
研究分野:  

Neurological Disease

TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ). TML-6 can upregulate Apo E, suppress NF-κB and mTOR, and increase the activity of the anti-oxidative Nrf2 gene. TML-6 has the potential for Alzheimer’s disease (AD) research .
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製品番号: HY-136477
CAS 番号: 27060-70-4
純度:  99.84%
別名: PGV-1
Target:  

Apoptosis COX VEGFR NF-κB

研究分野:  

Cancer

Pentagamavunon-1 (PGV-1), a Curcumin analog with oral activity, targets on several molecular mechanisms to induce apoptosis including inhibition of angiogenic factors cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF). PGV-1 inhibits NF-κB activation .
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製品番号: HY-P5485
CAS 番号: 271798-75-5
Target:  

Bacterial

研究分野:  

Others

Dabcyl-QALPETGEE-Edans is a synthetic peptide substrate for fluorescence resonance energy transfer (FRET) detection of Sortase A (SrtA) enzymatic activity. Dabcyl-QALPETGEE-Edans is labeled at both ends with the fluorescent group Edans (donor) and the quencher Dabcyl (acceptor), respectively. Dabcyl-QALPETGEE-Edans's central sequence contains a conserved motif specifically recognized by SrtA. Dabcyl-QALPETGEE-Edans demonstrates high sensitivity in vitro assays, enabling precise determination of the half-maximal inhibitory concentration of SrtA .
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製品番号: HY-W110707
CAS 番号: 143-27-1
別名: Hexadecylamine
研究分野:  

Cancer

Cetylamine (Hexadecylamine) is an amphipathic hexadecyl alkylamine. Cetylamine enhances phase separation of aqueous PVA solutions, promotes the formation of PVA crystalline domains while remaining amorphous itself, and enables the preparation of surfactant-free, solvent-free, and crosslinker-free PVA hydrogels via freeze-thaw blending. Cetylamine can serve as the cationic surfactant component in ion-crosslinked micelles, which can load hydrophobic drugs and deliver them to breast cancer cells. Cetylamine is applicable to breast cancer-related research .
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製品番号: HY-N0007AR
CAS 番号: 24939-16-0
別名: Curcumin III (Standard); DidemethoxyCurcumin (Standard)
Bisdemethoxycucurmin (Standard) (Curcumin III (Standard)) is the analytical standard of Bisdemethoxycucurmin (HY-N0007A). This product is intended for research and analytical applications. Bisdemethoxycucurmin (Curcumin III) is a curcuminoid compound and an inhibitor of P-glycoprotein and ferroptosis. Bisdemethoxycucurmin exhibits multiple activities such as anti-oxidation, anti-inflammation and anti-tumor. Bisdemethoxycucurmin can be used for the research of tumors and inflammatory diseases .
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製品番号: HY-N0006R
CAS 番号: 22608-11-3
別名: Curcumin II (Standard); DesmethoxyCurcumin (Standard); MonodemethoxyCurcumin (Standard)
Demethoxycurcumin (Standard) is the analytical standard of Demethoxycurcumin. This product is intended for research and analytical applications. Demethoxycurcumin is one of the main active ingredients of curcumin, which has anti-inflammatory, antioxidant, antibacterial, anti-cancer and neuroprotective effects. Demethoxycurcumin is orally active. Demethoxycurcumin can be used in inflammation, cancer and Alzheimer's disease research [4] .
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製品番号: HY-N0006S1
別名: Curcumin II-d4; DesmethoxyCurcumin-d4; MonodemethoxyCurcumin-d4
Demethoxycurcumin-d4 is the deuterium labeled Demethoxycurcumin. Demethoxycurcumin (Curcumin II) is a major active curcuminoid; possess anti-inflammatory properties .
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製品番号: HY-N0893R
CAS 番号: 36062-04-1
別名: HZIV 81-2 (Standard)
Tetrahydrocurcumin (Standard) is the analytical standard of Tetrahydrocurcumin. This product is intended for research and analytical applications. Tetrahydrocurcumin is a Curcuminoid found in turmeric (Curcuma longa) that is produced by the reduction of Curcumin. Tetrahydrocurcumin inhibit CYP2C9 and CYP3A4.
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製品番号: HY-W509797
CAS 番号: 21618-92-8
5-(3',4'-Dihydroxyphenyl)-γ-valerolactone is an intestinal microbiota metabolite of (-)-Epicatechin (HY-N0001). 5-(3',4'-Dihydroxyphenyl)-γ-valerolactone downregulates TNF-α-stimulated phosphorylation of IKK and IκBα, inhibits the transcriptional activation of NF-κB, and suppresses the expression of adhesion molecules and chemokines. 5-(3',4'-Dihydroxyphenyl)-γ-valerolactone promotes autophagy, alleviates oxidative stress, maintains osteoblast differentiation, induces G1 phase arrest, inhibits adipogenesis, and scavenges ABTS free radicals. 5-(3',4'-Dihydroxyphenyl)-γ-valerolactone inhibits the adhesion of uropathogenic Escherichia coli to bladder epithelial cells; when used in combination with Curcumin (HY-N0005), it downregulates the NLRP3 and NOX2/Nrf2 signaling pathways, thereby reducing microglial activation. 5-(3',4'-Dihydroxyphenyl)-γ-valerolactone can be used in research related to diabetes, atherosclerosis, osteoporosis, obesity, neurodegenerative diseases involving microglial activation, and urinary tract infections [4] .
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製品番号: HY-N0007R
CAS 番号: 33171-05-0
別名: (E,E)-Curcumin III (Standard); (E,E)-DidemethoxyCurcumin (Standard)
(E,E)-Bisdemethoxycurcumin (Standard) is the analytical standard of (E,E)-Bisdemethoxycurcumin. This product is intended for research and analytical applications. (E,E)-Bisdemethoxycurcumin ((E,E)-Curcumin III) is a curcumin derivative with anti-inflammatory and anticancer activities [4] .
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製品番号: HY-179228
CAS 番号: 1246964-08-8
Target:  

CTLA-4 TGF-beta/Smad

研究分野:  

Cancer

AN02 is a derivative of Curcumin (HY-N0005). AN02 inhibits the proliferation and clonogenicity, migration and invasion of ovarian cancer cells. AN02 dose-dependently upregulates the expression of APC and mediates the degradation of CTLA-4 through SMAD4. In the small xenograft model, AN02 significantly inhibits tumor growth and reverses the tumor immune-suppressive microenvironment. AN02, when combined with Ipilimumab (HY-P9901), can enhance efficacy and inhibit epithelial-mesenchymal transition. AN02 can be used for the study of ovarian cancer .
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製品番号: HY-N0894R
CAS 番号: 36062-07-4
別名: HexahydrobisdemethoxyCurcumin (Standard)
Octahydrocurcumin (Hexahydrobisdemethoxycurcumin) is a hydrogenated derivative of curcumin and a metabolite of curcumin. Octahydrocurcumin is an orally active anticancer and anti-inflammatory agent, and is the final hydrogenated metabolite of Curcumin (HY-N0005) in vivo. Octahydrocurcumin exerts its anti-tumor and anti-inflammatory effects by inducing the mitochondrial apoptosis pathway and inhibiting the TAK1-NF-κB-COX-2 pathway, respectively .
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製品番号: HY-N7275
CAS 番号: 824951-60-2
Di-O-methyldemethoxycurcumin, a curcuminoid analog, inhibits IL-6 production with an EC50 of 16.20 μg/mL. Anti-inflammatory and antioxidant properties .
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製品番号: HY-135702
CAS 番号: 1258513-40-4
純度:  99.20%
Target:  

NF-κB

研究分野:  

Others

UBS109, as a curcumin analogue, can promote the differentiation and mineralization of osteoblasts. UBS109 shows to regulate bone cell function by activating Smad and inhibiting NF-kB. UBS109 can be used in bone tissue engineering and osteoporosis research .
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製品番号: HY-N0929R
CAS 番号: 36062-05-2
Hexahydrocurcumin (Standard) is the analytical standard of Hexahydrocurcumin. This product is intended for research and analytical applications. Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities .
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