36062-05-2
36062-05-2
Chemical Structure
Hexahydrocurcumin
- CAS No.: 36062-05-2
- Formula:C21H26O6
- Molecular Weight:374.43
IUPAC Name: 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)heptan-3-one
InChIKey: RSAHICAPUYTWHW-UHFFFAOYSA-N
SMILES: O=C(CC(O)CCC1=CC=C(O)C(OC)=C1)CCC2=CC=C(O)C(OC)=C2
Biological Activity: Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities[1][2].
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Hexahydrocurcumin | 98.57% | Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities. | ||||||||||||||||||||
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Hexahydrocurcumin (Standard) | 98.92% | Hexahydrocurcumin (Standard) is the analytical standard of Hexahydrocurcumin. This product is intended for research and analytical applications. Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities. | ||||||||||||||||||||
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Hexahydrocurcumin-d6 | Hexahydrocurcumin-d6 is the deuterium labeled Hexahydrocurcumin (HY-N0929). Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities. | |||||||||||||||||||||
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Tetrahydrocurcumin (Standard) | 99.35% | Tetrahydrocurcumin (Standard) is the analytical standard of Tetrahydrocurcumin. This product is intended for research and analytical applications. Tetrahydrocurcumin is a Curcuminoid found in turmeric (Curcuma longa) that is produced by the reduction of Curcumin. Tetrahydrocurcumin inhibit CYP2C9 and CYP3A4. | ||||||||||||||||||||
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Octahydrocurcumin | 99.25% | Octahydrocurcumin (Hexahydrobisdemethoxycurcumin) is an orally active anticancer and anti-inflammatory agent, and is the final hydrogenated metabolite of Curcumin (HY-N0005) in vivo. Octahydrocurcumin exerts its anti-tumor and anti-inflammatory effects by inducing the mitochondrial apoptosis pathway and inhibiting the TAK1-NF-κB-COX-2 pathway, respectively. | ||||||||||||||||||||
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(3R,5R)-Octahydrocurcumin | (3R,5R)-Octahydrocurcumin (Compound 7) is gut microbial metabolite of Curcumin (HY-N0005). (3R,5R)-Octahydrocurcumin exhibits neuroprotective efficacy against Aβ25-35-induced cell damage in SH-SY5Y, and anti-inflammatory activity against LPS-stimulated mouse microglial BV-2. | |||||||||||||||||||||
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(3S,5S)-Octahydrocurcumin | (3S,5S)-Octahydrocurcumin ((3S,5S)-Hexahydrobisdemethoxycurcumin) is a fungal metabolite that can be isolated from Curcuma longa. | |||||||||||||||||||||
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Antiviral agent 41 | Antiviral agent 41 (compound 5) is a diarylheptanoid isolated from Alpinia officinarum. Antiviral agent 41 exhibits potential antiviral activity against influenza virus in vitro. | |||||||||||||||||||||
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3''-Demethylhexahydrocurcumin | 3''-Demethylhexahydrocurcumin is a natural product. | |||||||||||||||||||||
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meso-Octahydrocurcumin | meso-Octahydrocurcumin is a natural phenolic compound. | |||||||||||||||||||||
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Demethoxyhexahydrocurcumin | Demethoxyhexahydrocurcumin is a Curcumin (HY-N0005) biotransformation metabolite and diarylheptanoid with antioxidant and antimicrobial activities. Demethoxyhexahydrocurcumin scavenges free radicals, inhibits cancer cell viability, and suppresses microbial growth. Demethoxyhexahydrocurcumin can be used for the research of colorectal cancer. | |||||||||||||||||||||
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5"-Methoxyhexahydrocurcumin | 5"-Methoxyhexahydrocurcumin is a natural phenolic compound. | |||||||||||||||||||||
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5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone | 99.76% | 5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone is a Phenols product that can be isolated from the rhizomes of Curcuma longa L.. | ||||||||||||||||||||
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References
- [1]. Srimuangwong K, et al. Hexahydrocurcumin enhances inhibitory effect of 5-fluorouracil on HT-29 human colon cancer cells. World J Gastroenterol. 2012 May 21;18(19):2383-9. [Content Brief]
- [2]. Li F, et al. In vitro antioxidant and anti-inflammatory activities of 1-dehydro-[6]-gingerdione, 6-shogaol, 6-dehydroshogaol and hexahydrocurcumin. Food Chem. 2012 Nov 15;135(2):332-7. [Content Brief]
