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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
235 Results for "
Integrin alpha
" in MedChemExpress (MCE) Product Catalog:
Products (235)
235 Results for "Integrin alpha" in MCE Product Catalog:
3
3 Cited Publications
Target:
Research Areas:
TC-I 15 (TC-I-15) is a type of allosteric collagen-binding integrin α2β1 inhibitor, and it also inhibits α1β1 and α11β1. TC-I 15 inhibits platelet adhesion to collagen and thrombus deposition. TC-I 15 prevents the formation of a pre-metastatic microenvironment by inhibiting the uptake of cancer-associated fibroblast (CAF) extracellular vesicles (EVs) by lung fibroblasts, which reduces the metastasis of salivary gland adenocystic carcinoma (SACC) to the lungs in mouse models, .
2
2 Cited Publications
Target:
Research Areas:
Integrin modulator 1 is a potent and selective α4β1 integrin agonist, with an IC50 of 9.8 nM for RGD-binding α4β1. Integrin modulator 1 increases cell adhesion mediated by α4β1 integrin, with an EC50 of 12.9 nM .
2
Target:
Research Areas:
2
2 Cited Publications
Target:
Research Areas:
BIO5192 is a selective and potent integrin α4β1 (VLA-4) inhibitor (Kd<10 pM). BIO5192 selectively binds to α4β1 (IC50=1.8 nM) over a range of other integrins. BIO5192 results in a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels .
2
2 Cited Publications
Cat. No.: HY-107589A
Purity: 99.96%
Target:
Research Areas:
BIO5192 hydrate is a selective and potent integrin α4β1 (VLA-4) inhibitor (Kd<10 pM). BIO5192 hydrate selectively binds to α4β1 (IC50=1.8 nM) over a range of other integrins. BIO5192 hydrate results in a 30-fold increase in mobilization of murine hematopoietic stem and progenitors (HSPCs) over basal levels .
2
2 Cited Publications
Cat. No.: HY-P9984
CAS No.: 1044758-60-2
Synonyms: rhuMAb Beta7; RG7413; PRO145223
1
1 Cited Publications
Cat. No.: HY-P990203
Target:
Research Areas:
1
1 Cited Publications
Cat. No.: HY-P77721A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ITGAV; Integrin, alpha V (Vitronectin Receptor, alpha Polypeptide, Antigen CD51); Prev. MSK8; Vitronectin Receptor; Prev. VNRA; Integrin alphaVbeta3; Prev. VTNR; Integrin, alpha V; Vitronectin Receptor Subunit alpha; CD51 Antigen; Integrin alpha-V; IDNDC
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P77719
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: ITGAV; Integrin, alpha V (Vitronectin Receptor, alpha Polypeptide, Antigen CD51); Prev. MSK8; Vitronectin Receptor; Prev. VNRA; Integrin alphaVbeta3; Prev. VTNR; Integrin, alpha V; Vitronectin Receptor Subunit alpha; CD51 Antigen; Integrin alpha-V; IDNDC
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P77720
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: ITGAV; Integrin, alpha V (Vitronectin Receptor, alpha Polypeptide, Antigen CD51); Prev. MSK8; Vitronectin Receptor; Prev. VNRA; Integrin alphaVbeta3; Prev. VTNR; Integrin, alpha V; Vitronectin Receptor Subunit alpha; CD51 Antigen; Integrin alpha-V; IDNDC
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P700762
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ITGAV; Integrin, alpha V (Vitronectin Receptor, alpha Polypeptide, Antigen CD51); Prev. MSK8; Vitronectin Receptor; Prev. VNRA; Integrin alphaVbeta3; Prev. VTNR; Integrin, alpha V; Vitronectin Receptor Subunit alpha; CD51 Antigen; Integrin alpha-V; IDNDC
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P73870
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ITGA6; CD49f; Integrin Subunit alpha 6; Very Late Activation Protein 6; VLA-6; Integrin, alpha 6; CD49 Antigen-Like Family Member F; Integrin alpha6B; Integrin alpha-6; CD49f Antigen; ITGA6A; JEB6; ITGA6B; ITGB4; GP150; Integrin Subunit Beta 4; Integrin,
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P77718
Purity: ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
Synonyms: ITGA5; Integrin alpha-F; Prev. FNRA; CDNA FLJ50382, Moderately Similar To Integrin alpha-5; CD49e; Very Late Activation Protein 5, alpha Subunit; Integrin, alpha 5 (Fibronectin Receptor, alpha Polypeptide); Fibronectin Receptor, alpha Subunit; Fibronectin
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P77716
Purity: ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
Synonyms: ITGA2B; Platelet Fibrinogen Receptor, alpha Subunit; Prev. GP2B; Platelet Glycoprotein IIb; GPIIb; alphaIIb Protein; Integrin alpha-IIb; Glycoprotein IIb; PPP1R93; CD41 Antigen; CD41B; BDPLT16; CD41; BDPLT2; Integrin, alpha 2b (Platelet Glycoprotein IIb O
Species:
Human
Source:
HEK293
1
1
1 Cited Publications
Cat. No.: HY-P700752
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ITGA2; alpha 2 Integrin; Prev. CD49B; Very Late Activation Protein 2 Receptor, alpha-2 Subunit; GPIa; Very Late Activation Receptor alpha-2 Subunit; CD49 Antigen-Like Family Member B; Human Platelet Alloantigen System 5; Platelet Membrane Glycoprotein Ia
Species:
Human
Source:
HEK293
1
1
1 Cited Publications
Cat. No.: HY-P83653
Synonyms: p150/95 Integrin alpha chain; Leu M5; SLEB6; ITGAX; CD11c; p150; Myeloid membrane antigen alpha subunit; Leukocyte surface antigen p150 95 alpha subunit; Integrin alpha-X; Integrin alpha X
Cat. No.: HY-175287
CAS No.: 3115530-47-4
α5β1 integrin agonist-2 (Compound 2) is a selective α5β1 integrin agonist (EC50 = 45.98 nM). α5β1 integrin agonist-2 induces integrin activation. α5β1 integrin agonist-2 is applicable to the research of leukemia .
Cat. No.: HY-124686
CAS No.: 859218-37-4
Target:
Research Areas:
ER-464195-01 is an orally active calreticulin (CRT) and integrin α subunits (ITGAs) binding inhibitor. ER-464195-01 inhibits leukocyte infiltration and subsequent inflammatory cascade reactions by dissociating the binding between CRT and ITGA. ER-464195-01 down-regulates the expression of pro-inflammatory genes (such as TNF-α, IL-1β, IL-6, IL-17f) induced by DSS (HY-116282C), and inhibit the phosphorylation of STAT3 and the production of serum amyloid A (SAA). ER-464195-01 can be used for the study of inflammatory bowel disease (IBD) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
