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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
51 Results for "
Mevalonate
" in MedChemExpress (MCE) Product Catalog:
Products (51)
51 Results for "Mevalonate" in MCE Product Catalog:
Cat. No.: HY-164091A
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Mevalonate 5-phosphate trilithium is a substrate of phosphomevalonate kinase and mevalonate-5-phosphate decarboxylase .
Cat. No.: HY-113037CS
Synonyms: Farnesyl diphosphate-d2 triammonium
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Synonyms: (±)-Mevalonolactone-d7; Mevalolactone-d7
Cat. No.: HY-113037B
CAS No.: 372-97-4
Synonyms: Farnesyl diphosphate
Research Areas:
Farnesyl pyrophosphate is a metabolic intermediate in the mevalonate (MVA) pathway. It is a TRP channel (TRPM2) agonist that triggers Ca2+ influx and cell death. Farnesyl pyrophosphate is a key branch substrate for cholesterol synthesis, ubiquinone synthesis, protein farnesylation, and geranylgeranyl pyrophosphate (GGPP) synthesis. Farnesyl pyrophosphate is used in research on cerebral ischemia, neurodegenerative diseases, pancreatic cancer, inflammation, and autoimmune diseases.
Cat. No.: HY-19671
CAS No.: 126411-13-0
Synonyms: SR-45023A; SR 9223i; SK&F-99085
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Apomine (SR-45023A) is an orally active antineoplastic agent that inhibits the mevalonate/isoprenoid pathway in cholesterol synthesis. Apomine can accelerate the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR). Apomine can also inhibit the growth of various types of cancer cells, including lung cancer, colon cancer, breast cancer, and skin cancer. Apomine is able to induce apoptosis in tumor cell lines derived from leukemia, colon cancer, liver cancer, ovarian cancer, and breast cancer .
Cat. No.: HY-164091
CAS No.: 73566-35-5
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Mevalonate 5-phosphate is a substrate of phosphomevalonate kinase and mevalonate-5-phosphate decarboxylase .
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Cat. No.: HY-113071C
CAS No.: 32451-23-3
Synonyms: (S)-MVA
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Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease
(S)-Mevalonic acid is the isomer of Mevalonic acid (HY-113071). Mevalonic acid ((S)-DCIT) is a precursor substance of the mevalonate pathway, which is essential for cell growth and proliferation. Mevalonic acid is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid can be used in studies of myopathy and heart failure .
Cat. No.: HY-W011209R
CAS No.: 7724-76-7
Synonyms: Riboprine (Standard)
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Cat. No.: HY-18714
CAS No.: 329059-55-4
BRD7116 is a cell-non-autonomous inhibitor of leukemic stem cells (LSCs). BRD7116, without directly contacting LSCs, can inhibit LSCs merely by altering the microenvironment. BRD7116 also has any cell-autonomous effects on LSCs and induces transcriptional changes consistent with myeloid differentiation. BRD7116 can be used for the study of leukemia .
Cat. No.: HY-113071AR
CAS No.: 2618458-93-6
Synonyms: MVA lithium salt (Standard)
Cat. No.: HY-N9923
CAS No.: 206440-72-4
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Cat. No.: HY-W011474S
CAS No.: 174873-05-3
Cat. No.: HY-W415921
CAS No.: 60299-43-6
Cat. No.: HY-107855S1
CAS No.: 61219-76-9
Synonyms: (±)-Mevalonolactone-d3; Mevalolactone-d3
Cat. No.: HY-151965
CAS No.: 3037689-82-7
Antimalarial agent 18 is an potent antimalarial agent, based on electronic, highly lipophilic and siderophoric properties. Antimalarial agent 18 belongs to acyloxymethyl series, as a fosmidomycin surrogate, which is potent IspC inhibitor against the non-mevalonate isoprenoid biosynthesis pathway. Antimalarial agent 18 inhibits P. falciparum (IC50=50 nM) and A. baumanii (IC50=390 nM) .
Cat. No.: HY-107855R
CAS No.: 674-26-0
Synonyms: (±)-Mevalonolactone (Standard); Mevalolactone (Standard)
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Cat. No.: HY-B0515R
CAS No.: 138926-19-9
Synonyms: BM-210955 (Standard); RPR-102289A (Standard)
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Ibandronate Sodium Monohydrate (BM-210955; RPR-102289A) (Standard) is the analytical standard of Ibandronate Sodium Monohydrate (HY-B0515). This product is intended for research and analytical applications. Ibandronate Sodium Monohydrate (BM-210955; RPR-102289A) is an orally active, selective inhibitor of farnesyl pyrophosphate synthase (FPP synthase). Ibandronate Sodium Monohydrate can block the mevalonate pathway to inhibit the isoprenylation modification of small GTPases (such as RAS, RHO family proteins), induce tumor cell apoptosis and inhibit bone resorption. Ibandronate Sodium Monohydrate inhibits tumor cell proliferation (such as ER + breast cancer cells), promotes the expression of the pro-apoptotic gene FAS, and can produce synergistic anti-tumor effects with anti-estrogen compounds. Ibandronate Sodium Monohydrate is used in the study of osteoporosis and bone metastatic tumors (such as breast cancer bone metastasis) .
Cat. No.: HY-N19716
CAS No.: 34427-31-1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
