517-43-1
Chemical Structure
Sennoside
- CAS No.: 517-43-1
- Formula:C42H38O20
- Molecular Weight:862.74
InChIKey: IPQVTOJGNYVQEO-JLDSCGAUSA-N
SMILES: OC[C@@H](O1)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC2=CC=CC3=C2C(C4=C(C=C(C(O)=O)C=C4O)C3C5C6=C(C(C7=C5C=C(C(O)=O)C=C7O)=O)C(O[C@H]8[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O8)=CC=C6)=O
Biological Activity: Sennoside is an orally active apoptosis inducer and stimulant laxative, found in Senna (Cassia angustifolia). Sennoside induces overexpression of wild-type p53 and p21/WAF as part of pathways mediating colonic epithelial cell apoptosis. Sennoside stimulates colonic peristalsis, reverses net water, sodium, chloride absorption to secretion and enhances potassium and calcium secretion. Sennoside increases paracellular permeability to small molecules, accelerates colon transit and softens fecal pellets. Sennoside can be used for the research of constipation, melanosis coli, and colorectal cancer[1][2][3].
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Sennoside | Sennoside is an orally active apoptosis inducer and stimulant laxative, found in Senna (Cassia angustifolia). Sennoside induces overexpression of wild-type p53 and p21/WAF as part of pathways mediating colonic epithelial cell apoptosis. Sennoside stimulates colonic peristalsis, reverses net water, sodium, chloride absorption to secretion and enhances potassium and calcium secretion. Sennoside increases paracellular permeability to small molecules, accelerates colon transit and softens fecal pellets. Sennoside can be used for the research of constipation, melanosis coli, and colorectal cancer. | |||||||||||||||||||||
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- [1]. van Gorkom BA, et al. Apoptosis induction by sennoside laxatives in man; escape from a protective mechanism during chronic sennoside use?. J Pathol. 2001;194(4):493-499. [Content Brief]
- [2]. Rama Reddy NR, et al. Next Generation Sequencing and Transcriptome Analysis Predicts Biosynthetic Pathway of Sennosides from Senna (Cassia angustifolia Vahl.), a Non-Model Plant with Potent Laxative Properties. PLoS One. 2015 Jun 22;10(6):e0129422. [Content Brief]
- [3]. Leng-Peschlow E. Sennoside-induced secretion and its relevance for the laxative effect. Pharmacology. 1993 Oct;47 Suppl 1:14-21. [Content Brief]
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