23 Results for "

RXFP1

" in MedChemExpress (MCE) Product Catalog:
Products (23)

23 Results for "RXFP1" in MCE Product Catalog:

Cat. No.: HY-P992258

Target:  

RXFP Receptor

Research Areas:  

Inflammation/Immunology

Anti-LGR7 Antibody is a monoclonal antibody targeting LGR7/RXFP1. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-LGR7 Antibody, please refer to Mouse IgG2a kappa, Isotype Control (HY-P99978).
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Cat. No.: HY-P11625
Target:  

RXFP Receptor

Research Areas:  

Cardiovascular Disease

R9-13 is a fatty acid-conjugated relaxin and an agonist of LGR7 (RXFP1). R9-13 induces sustained pubic symphysis elongation in estrogen-pretreated mice. R9-13 exhibits long-acting pharmacokinetic profiles in rodents, with in vivo activity lasting up to one week after administration. R9-13 can be used in studies related to acute heart failure [1].
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Cat. No.: HY-P992108
CAS No.: 3061442-66-5
Synonyms: RELAX10

Research Areas:  

Cardiovascular Disease

Efadirelaxin alfa (RELAX10) is a highly selective agonist of relaxin/insulin-like family peptide receptor RXFP1. After subcutaneous administration in animal experiments, Efadirelaxin alfa exhibits a significantly prolonged terminal half-life (7 days in mice, 3.75 days in rats), and shows no activity against related receptors such as RXFP2 and RXFP3. Efadirelaxin alfa has significant anti-cardiac hypertrophy and anti-fibrotic effects. Efadirelaxin alfa effectively attenuates and reverses cardiac hypertrophy and collagen deposition by regulating the TGF-β1/Smad2 and AKT/eNOS signaling pathways. Efadirelaxin alfa improves cardiac systolic function without causing fluctuations in blood pressure or heart rate, demonstrating favorable safety. Efadirelaxin alfa is currently mainly used in studies related to heart failure [1].
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