146 Results for "

circulation

" in MedChemExpress (MCE) Product Catalog:
Products (146)

146 Results for "circulation" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-16940
CAS No.: 474-73-7
Synonyms: 24S-OHC; 24S-HC; Cerebrosterol
24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators .
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1
1 Cited Publications
Cat. No.: HY-142978
CAS No.: 156543-00-9
Synonyms: DSPE-mPEG2000
Target:  

Liposome

Research Areas:  

Others

18:0 mPEG2000 PE (DSPE-mPEG2000) ammonium is a kind of amphiphilic polymer material. 18:0 mPEG2000 PE ammonium combines hydrophobic lipids (18:0 stearic acid chain) with hydrophilic polyethylene glycol (2 kDa) chains to form amphiphilic molecules, which are used to construct stable liposomes/nanoparticles, thereby enhancing drug delivery, prolonging circulation time, and achieving targeted effects through its functional terminal groups (usually biotin or carboxyl groups). 18:0 mPEG2000 PE ammonium can be used for the research of nanoprobes and drug delivery .
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Cat. No.: HY-14905
CAS No.: 4105-38-8
Purity:  99.95%
Synonyms: Tri-O-acetyl uridine
Target:  

Drug Derivative

Research Areas:  

Neurological Disease

Uridine triacetate (Tri-O-acetyl uridine) is an orally active proagent of Uridine (HY-B1449). Uridine triacetate is quickly absorbed in the gut, and is rapidly deacetylated in the circulation to yield free uridine. Uridine triacetate is used for the research of 5-fluorouracil (5-FU) and capecitabine toxicity, or early-onset cardiac or central nervous system (CNS) .
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Cat. No.: HY-124265
CAS No.: 17320-10-4
Purity:  99.96%
4β-Hydroxycholesterol is a major Cholesterol (HY-N0322) metabolite and a precursor in the synthesis of bile acids that is found in human circulation .
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Cat. No.: HY-144004A
CAS No.: 474922-22-0
Purity:  ≥95.0%
Synonyms: DSPE-PEG5000 Maleimide ammonium; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-5000] ammonium
Target:  

Liposome

Research Areas:  

Others

DSPE-PEG-Maleimide has DSPE phospholipid and maleimide to prepare nanostructured lipid carrier. DSPE-PEG-Maleimide extends blood circulation time and higher stability for encapsulated agents . DSPE-PEG5000-Mal ammonium contains PEG5000.
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Cat. No.: HY-141892A
CAS No.: 1403744-37-5
Purity:  ≥96.0%
Target:  

Liposome

Research Areas:  

Others

DSPE-PEG2000 Carboxylic acid sodium is a PEG-lipid that can be used in the preparation of drug delivery nanoparticles .
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Cat. No.: HY-B2141
CAS No.: 621-72-7
Bendazol is an orally effective antihypertensive agent. Bendazol acts directly on vascular smooth muscle to dilate blood vessels and reduce peripheral resistance, thereby improving blood circulation. Bendazol significantly inhibits the development of myopia in rabbit models. Bendazol can regulate kidney function by increasing the activity of NO synthase in the rat model of nephrogenic hypertension. In addition, Bendazol has an effect on sexual behavior and spermatogenesis in male rats .
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Cat. No.: HY-124265S
CAS No.: 1246302-80-6
Purity:  99.70%
4β-Hydroxycholesterol-d7 is the deuterium labeled 4β-Hydroxycholesterol (HY-124265). 4β-Hydroxycholesterol is a major Cholesterol (HY-N0322) metabolite and a precursor in the synthesis of bile acids that is found in human circulation .
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Cat. No.: HY-P2752
CAS No.: 9004-02-8
Synonyms: LPL
Target:  

Endogenous Metabolite

Research Areas:  

Metabolic Disease Cancer

Lipoprotein lipase, Pseudomonas sp (LPL) is a multifunctional enzyme from adipose tissue, heart and skeletal muscle, islets and macrophages. Lipoprotein lipase promotes normal lipoprotein metabolism, delivery and utilization of tissue-specific substrates. Lipoprotein lipase catalyzes the rate-limiting step of lipids in blood circulation .
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Cat. No.: HY-124265S2
CAS No.: 1363529-44-5
Purity:  99.79%
4β-Hydroxycholesterol-d4 is the deuterium labeled 4β-Hydroxycholesterol (HY-124265) . 4β-Hydroxycholesterol is a major Cholesterol (HY-N0322) metabolite and a precursor in the synthesis of bile acids that is found in human circulation .
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Cat. No.: HY-113257
CAS No.: 38339-02-5
Synonyms: DA-4S; Dopamine 4-Sulfate
Target:  

Drug Metabolite

Research Areas:  

Neurological Disease

Dopamine 4-sulfate (DA-4S) is an inactive metabolite of the catecholamine dopamine. It is formed from dopamine by the sulfotransferase (SULT) isoform SULT1A3. Dopamine 4-O-sulfate is found at lower levels in the brain and circulation than dopamine 3-O-sulfate.
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Cat. No.: HY-N2101
CAS No.: 72896-40-3
Benzoyloxypaeoniflorin, isolated from the root of Paeonia suffruticosa, is a tyrosinase inhibitor against mushroom tyrosinase with IC50 of 0.453 mM. Benzoyloxypaeoniflorin is NF-κB Inhibitor and contributes to improving blood circulation through its inhibitory effect on both platelet aggregation and blood coagulation .
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Cat. No.: HY-W016289
CAS No.: 642-71-7
Synonyms: 3,4,5-Trimethoxyphenol
Antiarol (3,4,5-Trimethoxyphenol) is a phenolic compound present in the trunk of Coffea canephora. Antiarol is a metabolite produced by chicken cecal microbes, whose cecal content changes dynamically with the severity of wooden breast (WB; a muscle disease prevalent in broilers) and enters the plasma through circulation .
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Cat. No.: HY-110207
CAS No.: 677773-91-0
Purity:  98.52%
Research Areas:  

Inflammation/Immunology

SM-324405 is a TLR7 agonistic antedrug (EC50 = 50 nM), with pEC50 values of 7.3 and 6.6 for human TLR7 and Rat TLR7, respectively. SM-324405 is used for immunoresearch of allergic diseases. An antedrug is defined as a locally active compound that is designed to be rapidly metabolized to an inactive form upon entry into the circulation and prevents systemic toxicity by losing its agonistic activity in a plasmatic environment .
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Cat. No.: HY-140699
CAS No.: 92451-01-9
Purity:  ≥98.0%
Synonyms: mPEG10000-SC; mPEG10000-Succinimidyl ester
m-PEG10000-NHS ester (mPEG10000-SC) is a pegylation reagent that targets the primary amino groups of branched polyethyleneimine on gold nanoparticles. m-PEG1000-NHS ester covalently links its PEG moiety to target amino groups via amine-mediated coupling chemistry. m-PEG1000-NHS ester helps improve the biocompatibility of modified gold nanoparticles used as CT contrast agents and prolongs their blood circulation time.
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Cat. No.: HY-W014394
CAS No.: 82654-98-6
Vanillyl butyl ether is a major contributor to the characteristic flavor and fragrance of vanilla. Vanillyl butyl ether is one of the eco-friendly and nontoxic substances. Vanillyl butyl ether exhibits mutually inhibitory effects on mammalian TRPV1 and TRPM8 channels. Vanillyl butyl ether shows repellency activity against Tribolium castaneum, T. confusum and L. bostrychophila. Vanillyl butyl ether acts as a mild warming agent, providing a warming sensation and enhancing blood circulation .
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Cat. No.: HY-143209B
CAS No.: 145035-96-7
Target:  

Liposome

Research Areas:  

Cancer

DSPE-PEG3400 is a phospholipid-PEG polymer conjugate that can be used in drug delivery applications. DSPE-PEG3400 serves as a material for preparing nanocarriers, which is used to prolong blood circulation time, enhance stability and improve encapsulation efficiency .
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Cat. No.: HY-W100959
CAS No.: 527-17-3
Synonyms: Tetramethylquinone
Target:  

Drug Derivative

Research Areas:  

Others

Duroquinone (Tetramethylquinone) is a model compound of amphiphilic quinone, which can be used as an oxidative-reductive activity probe. Duroquinone can be easily reduced by biological systems to hydrogen peroxide (DQH₂) or semi-quinone free radicals (DQ•⁻). Duroquinone can freely pass through the cell membrane, facilitating the study of the electron transfer process inside and outside the cells. Duroquinone can be used to investigate the relationship between metabolism in the pulmonary circulation and endothelial cells .
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Cat. No.: HY-140700
CAS No.: 92451-01-9
Purity:  ≥98.0%
Synonyms: mPEG20000-SC; mPEG20000-Succinimidyl ester
m-PEG20000-NHS ester (mPEG20000-SC) is a pegylation reagent that targets the primary amino groups of branched polyethyleneimine on gold nanoparticles. m-PEG1000-NHS ester covalently links its PEG moiety to target amino groups via amine-mediated coupling chemistry. m-PEG1000-NHS ester helps improve the biocompatibility of modified gold nanoparticles used as CT contrast agents and prolongs their blood circulation time.
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Cat. No.: HY-165156
CAS No.: 459429-07-3
Synonyms: 1,2-DPPE-MPEG(2000)
Target:  

Liposome

Research Areas:  

Others

DPPE-MPEG 2000 (1,2-DPPE-MPEG(2000)) is a PEG-modified lipids. DPPE-MPEG 2000 can reduce the nonspecific adsorption of protein and prolong circulation time in vivo .
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