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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
36 Results for "
long-term memory
" in MedChemExpress (MCE) Product Catalog:
Products (36)
36 Results for "long-term memory" in MCE Product Catalog:
製品番号: HY-P11092
Target:
研究分野:
製品番号: HY-156104
CAS 番号: 2481744-33-4
研究分野:
CaMKIIα-PHOTAC is a photochemically targeted chimera (PHOTAC) targeting Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα). Molecules such as PHOTAC can catalyze the ubiquitination and degradation of target proteins through the endogenous proteasome under specific wavelengths of light. CaMKIIα-PHOTAC reduces synaptic function under light conditions, and it attenuates the intensity of evoked field excitatory postsynaptic potentials in the mouse hippocampus in response to physiological stimuli. CaMKIIα-PHOTAC plays a critical role in maintaining long-term potentiation and memory capacity in subcellular dendritic domains .
製品番号: HY-P1426A
Target:
研究分野:
製品番号: HY-107111A
CAS 番号: 932373-86-9
Target:
研究分野:
GSK1034702 hydrochloride is an orally active and allosteric agonist of M1 mAChR (pEC50=8.1) that can cross the blood-brain barrier. GSK1034702 hydrochloride activates the Gq/11 protein-mediated signaling pathway, enhancing neuronal firing and long-term potentiation (LTP) in the CA1 region of the hippocampus. GSK1034702 hydrochloride can modulate hippocampal function, improve memory encoding in the nicotine withdrawal cognitive dysfunction model, and show pro-cognitive effects in rodents. GSK1034702 hydrochloride can be used for the study of the mechanisms of cognitive impairment diseases such as Alzheimer's disease, and has certain peripheral M receptor activation-related side effects (such as gastrointestinal reactions) .
製品番号: HY-116488
CAS 番号: 1778682-59-9
Target:
研究分野:
IND8 is a α7 nAChR activator and cognitive enhancer. IND8 mediates cognitive enhancement by activating α7 nAChR . IND8 improves spatial working memory, episodic short-term memory and spatial long-term memory in amnesic mice induced by Scopolamine (HY-N0296). IND8 improves memory function in mice with delayed natural memory decline. IND8 can be used in research related to Alzheimer's disease .
製品番号: HY-N2125R
CAS 番号: 174972-80-6
Category:
製品番号: HY-P1399A
別名: Myr-Pep2m TFA
Target:
研究分野:
製品番号: HY-P1399
CAS 番号: 1423381-07-0
別名: Myr-Pep2m
Target:
研究分野:
製品番号: HY-103477
CAS 番号: 947540-06-9
Target:
研究分野:
MAO-B-IN-51 (Compound 8f) is a selective, blood-brain-barrier permeable, orally active MAO-B inhibitor with an
IC50 of 48．9 nM (MDS). MAO-B-IN-51 enhances long-term memory .
製品番号: HY-W754293
CAS 番号: 23513-72-6
別名: V0191; DMAE pidolate; DMAE PCA
Target:
研究分野:
Deanol pidolate (V0191; DMAE pidolate) is an orally active pro-cholinergic agent that improves cognitive symptoms by increasing the release of acetylcholine (Ach) and avoids the typical side effects of cholinesterase inhibitors. Deanol pidolate can alleviate the harmful effects of scopolamine on long-term memory and restore to baseline levels more quickly. Deanol pidolate can be used in research on Alzheimer's disease .
製品番号: HY-181865
研究分野:
BuChE-IN-22 is a pseudo-irreversible butyrylcholinesterase (BuChE) inhibitor, with IC50 values of 4 nM and 157 nM against hBuChE and hAChE, respectively. It also acts as a prodrug of 7-hydroxysertraline. BuChE-IN-22 releases 7-hydroxysertraline during BuChE inhibition. BuChE-IN-22 completely reverses Aβ25-35-induced short-term and long-term memory impairments in a mouse model of Alzheimer's disease. BuChE-IN-22 can be used in research related to Alzheimer's disease .
製品番号: HY-N2332
CAS 番号: 21019-30-7
別名: MLA
製品番号: HY-107111R
CAS 番号: 932373-87-0
Target:
研究分野:
GSK1034702 (Standard) is the analytical standard of GSK1034702 (HY-107111). This product is intended for research and analytical applications. GSK1034702 is an orally active and allosteric agonist of M1 mAChR (pEC50=8.1) that can cross the blood-brain barrier. GSK1034702 activates the Gq/11 protein-mediated signaling pathway, enhancing neuronal firing and long-term potentiation (LTP) in the CA1 region of the hippocampus. GSK1034702 can modulate hippocampal function, improve memory encoding in the nicotine withdrawal cognitive dysfunction model, and show pro-cognitive effects in rodents. GSK1034702 can be used for the study of the mechanisms of cognitive impairment diseases such as Alzheimer's disease, and has certain peripheral M receptor activation-related side effects (such as gastrointestinal reactions) .
製品番号: HY-N2332AR
CAS 番号: 351344-10-0
別名: MLA citrate (Standard)
研究分野:
Methyllycaconitine citrate (Standard) is the analytical standard of Methyllycaconitine citrate (HY-N2332A). This product is intended for research and analytical applications. Methyllycaconitine (MLA) citrate is a blood-brain barrier-permeable antagonist of α7 nicotinic acetylcholine receptor (α7nAChR) with an IC50 of 2 nM. Methyllycaconitine citrate inhibits Aβ25-35-induced autophagy by restoring the mTOR pathway, and prevents reactive oxygen species (ROS) production, microglial activation, reduced dopamine uptake, loss of dopaminergic terminals and catecholamine secretion. Methyllycaconitine citrate induces hippocampal glutamate efflux, enhances long-term potentiation, and improves memory acquisition. Methyllycaconitine citrate can be used in research related to Alzheimer's disease, cerebral palsy, ParKinson's disease and schizophrenia .
製品番号: HY-176036A
Target:
研究分野:
MS1262 TFA is a blood-brain barrier-permeable, selective inhibitor of histone methyltransferases G9a (EHMT2) and GLP (EHMT1), with an IC50 of 19 nM and a Kd of 74 nM against G9a, and an IC50 of 6 nM and a Kd of 19 nM against GLP. MS1262 TFA reduces the dimethylation level of histone H3 lysine 9 and decreases the size of Aβ plaques. MS1262 TFA restores hippocampal long-term potentiation (LTP) and miniature excitatory postsynaptic current (sEPSC) frequency, ameliorates spatial memory deficits, and reverses anxiety-like and depression-like behaviors in AD model mice. MS1262 TFA reverses the expression/phosphorylation levels of early AD biomarkers, providing support for stage-specific diagnosis of AD. MS1262 TFA reduces the risk of thrombus rupture. MS1262 TFA can be used in research related to Alzheimer's disease, colorectal cancer, and triple-negative breast cancer .
製品番号: HY-110120R
CAS 番号: 1059070-10-8
研究分野:
DSR-6434 (Standard) is the analytical standard of DSR-6434 (HY-110120). This product is intended for research and analytical applications. DSR-6434 is a potent and selective Toll-like receptor 7 (TLR7) agonist, with EC50s of 7.2 nM and 4.6 nM for human and mice TLR7, respectively. DSR-6434 has a strong antitumor effect .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
