2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. IND8

IND8 is a α7 nAChR activator and cognitive enhancer. IND8 mediates cognitive enhancement by activating α7 nAChR . IND8 improves spatial working memory, episodic short-term memory and spatial long-term memory in amnesic mice induced by Scopolamine (HY-N0296). IND8 improves memory function in mice with delayed natural memory decline. IND8 can be used in research related to Alzheimer's disease.

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IND8

IND8 Chemical Structure

CAS No. : 1778682-59-9

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IND8 Related Antibodies

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Description

IND8 is a α7 nAChR activator and cognitive enhancer. IND8 mediates cognitive enhancement by activating α7 nAChR . IND8 improves spatial working memory, episodic short-term memory and spatial long-term memory in amnesic mice induced by Scopolamine (HY-N0296). IND8 improves memory function in mice with delayed natural memory decline. IND8 can be used in research related to Alzheimer's disease[1].

In Vitro

IND8 potently binds to and activates α7-nAChRs in cells expressing LGIC receptors, with a Kd of 0.12 μM and an EC50 of 0.03 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IND8 Related Antibodies
In Vivo

IND8 (5-50 μmol/kg; i.p.; single administration) rescues scopolamine (HY-N0296)-induced cognitive impairment in male ICR mice, and significantly improves their spatial working memory, episodic short-term memory and spatial reference memory[1].
IND8 (10-25 μmol/kg; intraperitoneal injection; single administration) improves cognitive function in mice with delayed-induced natural memory decline[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice (male, 6-weeks of age, scopolamine-induced amnesia)[1]
Dosage: 5 μmol/kg (1.5 mg/kg); 10 μmol/kg (2.9 mg/kg); 25 μmol/kg (7.3 mg/kg); 50 μmol/kg (14.7 mg/kg)
Administration: i.p.; single dose
Result: Significantly reversed scopolamine-induced cognitive deficit, with percentage of unfamiliar arm exploration significantly higher than the scopolamine-treated group.
Increased discrimination index (DI) at 10 μmol/kg and 50 μmol/kg compared to the scopolamine-treated group, and exploration time of the novel object was significantly longer than the familiar object.
Increased time spent in the target quadrant at 25 μmol/kg and 50 μmol/kg compared to the scopolamine-treated group.
Molecular Weight

293.37

Formula

C17H19N5
CAS No.
SMILES

N1(C2CN3CCC2CC3)N=NC(C4=CC5=C(NC=C5)C=C4)=C1
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Purity & Documentation
References
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IND8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IND81778682-59-9IND 8IND-8nAChRNicotinic acetylcholine receptorsmale ICR miceα7 nicotinic acetylcholine receptoralzheimer's diseaseα7-nAChRsscopolamine-induced amnesic micespatial working memoryspatial reference memoryepisodic short-term memoryspatial long-term memoryLGIC receptorsInhibitorinhibitorinhibit

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