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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
41 Results for "
Azoles
" in MedChemExpress (MCE) Product Catalog:
Products (41)
41 Results for "Azoles" in MCE Product Catalog:
Cat. No.: HY-113648
CAS No.: 1025400-45-6
LP10 is a non-azole CYP51 inhibitor with activity against Trypanosoma cruzi infection. Treatment with LP10 blocks the 14α-demethylation step, leading to disruption of the parasite cell membrane and ultimately triggering the death of important clinically relevant amoeba stages .
Cat. No.: HY-B1118S1
Synonyms: RP-14539-13C2, 15N2; PM-185184-13C2, 15N2
Cat. No.: HY-155709
CAS No.: 2925307-52-2
Antifungal agent 67 (compound 9) is an imidazole antifungal agent that is effective against Candida. Antifungal agent 67 has a CC50 value of 33.6 μM on healthy neonatal rat cardiomyoblasts .
Cat. No.: HY-155710
CAS No.: 2925307-53-3
Antifungal agent 68 (compound 10) is an antifungal agent against Candida and Cryptococcus gattii. Antifungal agent 68 inhibits fungal ergosterol biosynthesis, possibly by targeting lanosterol 14α-demethylase (CYP51). There is an interaction between the imidazole ring of antifungal agent 68 and the heme group of CYP51 .
Cat. No.: HY-151439
CAS No.: 3033703-21-5
Antifungal agent 41 (compound B01) is an antifungal agent. Antifungal agent 41 shows inhibitory effect on Candida albicans in virto and vivo. Antifungal agent 41 can be used for the research of invasive fungal infections .
Cat. No.: HY-B1118S2
Synonyms: RP-14539-d4; PM-185184-d4
Cat. No.: HY-B1118S3
Synonyms: RP-14539-d3; PM-185184-d3
Cat. No.: HY-B0852S2
Cat. No.: HY-181404
Target:
Research Areas:
PA36-2 is an Mdr1 inhibitor and azole resistance reversal agent, with a IC50 of 1.0 μg/mL and a Kd of 4.209 μM against Candida albicans Mdr1. By effectively inhibiting the activity of the Mdr1 efflux pump, PA36-2 prevents the pumping of substrates out of cells, enhances the intracellular accumulation of azole antibiotics, and exerts a synergistic effect with antifungal agents such as Fluconazole (FLC) (HY-B0101). PA36-2 can be used in the research of azole-resistant candidiasis .
Cat. No.: HY-122380
CAS No.: 93479-96-0
Alteconazole is a compound with antifungal activity that belongs to the class of azole derivatives.
Cat. No.: HY-N19184
CAS No.: 2900278-39-7
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Cat. No.: HY-184165
F2F-202 is a selective HDAC6 inhibitor with an IC50 of 7.1 nM, exhibiting high selectivity toward HDAC1. F2F-202 does not directly bind to or inhibit the Hda1 protease activity of Candida albicans itself, but reduces the mRNA transcription level of the Hda1 gene. When combined with Voriconazole (HY-76200), F2F-202 decreases the yeast-hypha transition rate of azole-resistant Candida albicans and impairs the antioxidant response of azole-resistant Candida albicans. F2F-202 can be used in studies related to azole-resistant Candida albicans infections .
Cat. No.: HY-187652
CAS No.: 2883514-82-5
Synonyms: CMLD012336
Azoffluxin (CMLD012336) is a Cdr1 inhibitor. Azoffluxin enhances the activity of Fluconazole (HY-B0101) and other intracellular-acting antifungal agents against drug-resistant Candida. Azoffluxin is used for research on fungal efflux-mediated azole resistance and combined antifungal therapy .
Cat. No.: HY-D2977
Cat. No.: HY-W714186
CAS No.: 60207-93-4
Synonyms: Etaconazole
Etaconazol (Etaconazole) is an azole fungicide. Etaconazol possesses endocrine-disrupting potential and inhibits placental steroidogenesis by suppressing 3β-hydroxysteroid dehydrogenase (3β-HSD1). Etaconazol binds to the NAD +/steroid-binding site of the target enzyme and acts on both the free enzyme and enzyme-substrate complex to inhibit their activity .
Cat. No.: HY-184963
CAS No.: 913087-59-9
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Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease
Anticonvulsant agent 12 is a naphthalene-containing azole compound with anticonvulsant activity. Anticonvulsant agent 12 can be used in the research of central nervous system diseases including anxiety, depression, convulsion, epilepsy, migraine, bipolar disorder, substance abuse, smoking, ADHD, obesity, sleep disorders, stroke, neuropathic pain, cognitive impairment, neurodegenerative diseases and muscle spasms .
Cat. No.: HY-184587
Research Areas:
Antibacterial agent 356 is an orally active antibacterial agent. Antibacterial agent 356 binds to the Mrr1 transcription factor, inhibits the expression of the MDR1 efflux pump gene, reduces the efflux of Rhodamine 123, and increases the accumulation of intracellular substrates in drug-resistant Candida albicans cells. Antibacterial agent 356 induces mitochondrial membrane potential reduction and ROS accumulation in Candida albicans, inhibits the yeast-hypha transition process, and suppresses its biofilm formation. Antibacterial agent 356 reverses efflux pump-mediated drug resistance in azole-resistant Candida albicans with overexpressed Mdr1. Antibacterial agent 356 improves the survival rate of Galleria mellonella larvae infected with azole-resistant Candida albicans*CA632, and reduces the renal fungal load and renal tissue damage in infected BALB/c mice. Antibacterial agent 356 can be used for the research of Candida albicans infection .
Cat. No.: HY-164381
CAS No.: 74512-12-2
Omoconazole is an imidazole-derived azole antifungal agent. Omoconazole exhibits broad-spectrum in vitro activity against dermatophytes, yeasts, and dimorphic fungi, exerting fungistatic effects at low concentrations and fungicidal effects at high concentrations. Omoconazole accumulates in the skin, binds to keratin, and is slowly transferred from the stratum corneum to the viable epidermis. Omoconazole inhibits the growth of dermatophytes, impairs daughter cell separation in Candida albicans, induces cell wall thickening, disrupts intracellular cytoplasmic organelles, and leads to cell death. Omoconazole is used in studies related to dermatophytosis and superficial fungal infections .
Cat. No.: HY-W724326
Cat. No.: HY-N19799
CAS No.: 1464778-45-7
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
