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Anticonvulsant agent 12

Cat. No.: HY-184963

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Anticonvulsant agent 12

Anticonvulsant agent 12 is a naphthalene-containing azole compound with anticonvulsant activity. Anticonvulsant agent 12 can be used in the research of central nervous system diseases including anxiety, depression, convulsion, epilepsy, migraine, bipolar disorder, substance abuse, smoking, ADHD, obesity, sleep disorders, stroke, neuropathic pain, cognitive impairment, neurodegenerative diseases and muscle spasms.

For research use only. We do not sell to patients.

CAS No.: 913087-59-9
Formula: C₁₀H₁₀ClN₅O₂
Molecular Weight:267.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Anticonvulsant agent 12 Chemical Structure

CAS No.: 913087-59-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

Anticonvulsant agent 12 (compound 2) (100 μM; 1.5 h) exhibits weak binding activity to the GABA-A receptor TBPS site, with an inhibition rate of 11.2% at a concentration of 100 μM in rat whole brain rough membrane homogenate (cerebellum removed)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anticonvulsant agent 12 (compound 2) exhibits significant anxiolytic activity in mice, with a 180% increase in time spent in the light box, indicating a strong anxiolytic effect^[1].
Anticonvulsant agent 12 exhibits potent anticonvulsant activity, with a MES ED₅₀ of 8.6 mg/kg, reaching maximum efficacy 0.5 hours after administration^[1].
Anticonvulsant agent 12 exhibits potent anticonvulsant/anxiety-relieving activity, with a PTZ ED₅₀ of 5.9 mg/kg, and shows significant protective effect against pentylenetetrazol-induced seizures^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 913087-59-9
Molecular Weight 267.67
Formula C₁₀H₁₀ClN₅O₂
SMILES

O=C(N)OC(CN1N=NC=N1)C2=C(Cl)C=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Choi YM, et al. Neurotherapeutic azole compounds. WO2006112685 A1. 2006 Oct 26.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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