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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
66 Results for "
pDI
" in MedChemExpress (MCE) Product Catalog:
Products (66)
66 Results for "pDI" in MCE Product Catalog:
Cat. No.: HY-163351
Research Areas:
PDI-IN-2 is a highly selective PDI inhibitor. PDI-IN-2 has an IC50 of 0.63-4.01 μM against human PDI, and exhibits higher targeting specificity compared with ERp57 and ERp72. PDI-IN-2 inhibits platelet aggregation induced by U46619, collagen and tumor cells, and also blocks platelet-promoted tumor cell proliferation as well as the growth of multiple myeloma cells. PDI-IN-2 serves as an important tool reagent for research on multiple myeloma and associated thrombosis .
Cat. No.: HY-RS10265
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PDIA2 Human Pre-designed siRNA Set A contains three designed siRNAs for PDIA2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS18780
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P4hb Mouse Pre-designed siRNA Set A contains three designed siRNAs for P4hb gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS09945
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P4HB Human Pre-designed siRNA Set A contains three designed siRNAs for P4HB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-125832
CAS No.: 1415929-80-4
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PBDB-T is a wide bandgap polymer donor in Perylene diimide (PDI)-based polymer solar cells (PSCs) .
Cat. No.: HY-181574
CAS No.: 3097563-91-9
Target:
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PDI-IN-5 (compound 30z) is an allosteric-covalent inhibitor targeting protein disulfide isomerase (PDI) with a 2-chloro-pyrrolopyrimidin-4-one scaffold, with an IC50 of 0.4 μM. PDI-IN-5 exhibits selectivity for ERp57 and GPX4, and inhibits glioblastoma. PDI-IN-5 can be used in glioblastoma-related research .
Cat. No.: HY-RS09960
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PADI1 Human Pre-designed siRNA Set A contains three designed siRNAs for PADI1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS10267
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Research Areas:
Pdia3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pdia3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-116748
CAS No.: 257641-01-3
Target:
(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane is a small-molecule dithiol catalyst with a low thiol pKa value (8.3) and high reduction potential (-0.24 V), capable of mimicking PDI activity. It catalyzes the activation of scrambled ribonuclease A (scrambled ribonuclease A) and promotes the formation of native disulfide bonds, thereby significantly enhancing protein folding efficiency. Adding (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane to the culture medium of Saccharomyces cerevisiae can increase the secretion of exogenously expressed Schizosaccharomyces pombe acid phosphatase by more than threefold. (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane holds great potential for applications in protein production and secretion research .
Cat. No.: HY-W107464R
CAS No.: 2457232-14-1
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G6PDi-1 (Standard) is the analytical standard of G6PDi-1 (HY-W107464). This product is intended for research and analytical applications. G6PDi-1 is a reversible and non-competitive glucose-6-phosphate dehydrogenase (G6PD) inhibitor with an IC50 of 0.07 μM for human G6PD. G6PDi-1 depletes NADPH most strongly in lymphocytes. G6PDi-1 markedly decreases inflammatory cytoKine production in T cells .
Cat. No.: HY-W009300S
CAS No.: 81586-98-3
Synonyms: 4-OHE1-d4
Cat. No.: HY-W009300S1
Synonyms: 4-OHE1-13C6
Cat. No.: HY-179260A
Cat. No.: HY-P11591
CAS No.: 3110124-60-9
Synonyms: PSMA-DOTA-PEI2
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Cat. No.: HY-N19464
CAS No.: 16408-78-9
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Cat. No.: HY-138934
CAS No.: 1642375-66-3
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Bepristat 1a is a reversible, selective protein disulfide isomerase (PDI) inhibitor with an IC50 of 0.7 μM. Bepristat 1a inhibits platelet aggregation in laser-injured mouse arterioles. Bepristat 1a is applicable for research related to thrombosis .
Cat. No.: HY-181573
Research Areas:
TC8026 is an allosteric-covalent inhibitor targeting protein disulfide isomerase (PDI), with an IC50 of 7 μM against human PDI. TC8026 induces endoplasmic reticulum stress-mediated apoptosis. TC8026 is a hit compound with PDI inhibitory activity identified via high-throughput screening, and it can be used for the research of glioblastoma .
Cat. No.: HY-W851050A
CAS No.: 2284589-16-6
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BAP2 is an allosteric protein disulfide isomerase (PDI) inhibitor with a IC50 of 0.85 μM. BAP2 binds to His256 in the b′ domain of PDI and exerts inhibitory effects through allosteric binding to the b′ domain. BAP2 upregulates GRP78. BAP2 inhibits the growth of glioblastoma cells. BAP2 can be used in studies related to glioblastoma .
Cat. No.: HY-P71087
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: P4HB; Protein Disulfide Isomerase Family A, Member 1; Prev. ERBA2L; Cellular Thyroid Hormone-Binding Protein; Prev. PO4DB; Prolyl 4-Hydroxylase, Beta Polypeptide; pDIA1; Collagen Prolyl 4-Hydroxylase Beta; pDI; Procollagen-Proline, 2-Oxoglutarate 4-Dioxyg
Species:
Human
Source:
HEK293
Cat. No.: HY-100430R
CAS No.: 346640-08-2
Target:
Research Areas:
CCF642 (Standard) is the analytical standard of CCF642 (HY-100430). This product is intended for research and analytical applications. CCF642 is a potent protein disulfide isomerases (PDI) inhibitor with an IC50 of 2.9 μM. CCF642 causes acute endoplasmic reticulum (ER) stress in multiple myeloma cells accompanied by apoptosis-inducing calcium release. CCF642 has broad anti-multiple myeloma activity .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
