Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
76 Results for "
Ca2 /calmodulin
" in MedChemExpress (MCE) Product Catalog:
Products (76)
76 Results for "Ca2 /calmodulin" in MCE Product Catalog:
Cat. No.: HY-156104
CAS No.: 2481744-33-4
Research Areas:
CaMKIIα-PHOTAC is a photochemically targeted chimera (PHOTAC) targeting Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα). Molecules such as PHOTAC can catalyze the ubiquitination and degradation of target proteins through the endogenous proteasome under specific wavelengths of light. CaMKIIα-PHOTAC reduces synaptic function under light conditions, and it attenuates the intensity of evoked field excitatory postsynaptic potentials in the mouse hippocampus in response to physiological stimuli. CaMKIIα-PHOTAC plays a critical role in maintaining long-term potentiation and memory capacity in subcellular dendritic domains .
Cat. No.: HY-P3944
CAS No.: 82801-68-1
Target:
Research Areas:
Cat. No.: HY-P3943
CAS No.: 123067-01-6
Target:
Research Areas:
Cat. No.: HY-P2471
Target:
Research Areas:
Cat. No.: HY-124176
CAS No.: 85642-08-6
Target:
Research Areas:
L-6355 is an Amiodarone (HY-14187) related compound, which inhibits Ca 2+/calmodulin activated cyclic nucleotide phosphodiesterase with an IC50 value of 0.65 μM. L-6355 is promising for research of antiarrhythmic and antianginal agent .
Cat. No.: HY-P3811
CAS No.: 142828-10-2
Target:
Research Areas:
Cat. No.: HY-E70813
Target:
Research Areas:
CaMKK2 is a serine/threonine protein kinase and the central component of a Ca 2+-calmodulin activated signalling pathway. CaMKK2 is highly enriched in brain neurons and regulates energy metabolism and neuronal processes. CAMKK2 Recombinant Human Active Protein Kinase is obtained by expressing CAMKK2 proteins .
Cat. No.: HY-P1075A
Target:
Research Areas:
Cat. No.: HY-142087
CAS No.: 76265-41-3
Category:
Target:
Cat. No.: HY-103319R
CAS No.: 57265-65-3
Synonyms: R 24571 (Standard)
Target:
Research Areas:
Calmidazolium chloride (Standard) is the analytical standard of Calmidazolium chloride (HY-103319). This product is intended for research and analytical applications. Calmidazolium chloride (R 24571) is a calmodulin antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC50s of 0.15 and 0.35 μM, respectively . Also in anti-cancer research . Calmidazolium binds to calmodulin with a Kd of 3 nM.
Cat. No.: HY-105118
CAS No.: 109826-26-8
Synonyms: CGS-9343B free base; KW 5617 free base
Target:
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology
Zaldaride (CGS-9343B free base) is a potent, orally active and selective inhibitor of calmodulin. Zaldaride inhibits CaM (calmodulin)-stimulated cAMP phosphodiesterase activity, with an IC50 of 3.3 nM . Zaldaride prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na +, Ca 2+ and K + currents in PC12 cells and inhibits nAChR .
Cat. No.: HY-P1247A
Target:
Research Areas:
Cat. No.: HY-P1076
CAS No.: 261969-04-4
Target:
Research Areas:
Cat. No.: HY-108599R
CAS No.: 28399-31-7
Synonyms: FR236924 (Standard)
Target:
Research Areas:
DCP-LA (Standard) is the analytical standard of DCP-LA. This product is intended for research and analytical applications. DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCε. DCP-LA activates Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and inhibits protein phosphatase-1 (PP-1) to stimulate AMPA receptor exocytosis. DCP-LA inhibits activation of caspase-3/-9 and protects neurons at least in part from oxidative stress-induced apoptosis[1][2][3].
Cat. No.: HY-179016
Research Areas:
Ferroptosis/apoptosis inducer-3 (Compound 34) is a Ferroptosis and Apoptosis inducer. Ferroptosis/apoptosis inducer-3 induces both Ferroptosis and Apoptosis by causing G2/M phase cell cycle arrest, disrupting mitochondrial membrane potentials, promoting lipid peroxidation, and increasing the levels of Ca 2+ and Fe 2+ through the activation of calcium/calmodulin signaling. Ferraplasm/apoptosis inducer-3 shows anticancer effects against cervical cancer, adenocarcinoma, breast cancer, colon cancer, and colorectal carcinoma .
Cat. No.: HY-100912R
CAS No.: 61714-27-0
Research Areas:
W-7 (hydrochloride) (Standard) is the analytical standard of W-7 (hydrochloride) (HY-100912). This product is intended for research and analytical applications. W-7 hydrochloride is a selective calmodulin antagonist. W-7 hydrochloride inhibits the Ca2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase with IC50 values of 28 μM and 51 μM, respectively. W-7 hydrochloride induces apoptosis and has antitumor and vascular relaxing activity. W-7 hydrochloride is a blocker of Kv4.3 and can be used for research of arrhythmias .
Cat. No.: HY-116153
CAS No.: 1393102-59-4
Target:
Research Areas:
HUHS2002 is a free fatty acid derivative with the ability to enhance α7 cholinergic receptor activity. HUHS2002 enhances whole-cell membrane currents of α7 ACh receptors expressed in Xenopus oocytes in a concentration-dependent manner. The effects of HUHS2002 were blocked in the presence of the Ca2 /calmodulin-dependent protein kinase II (CaMKII) inhibitor KN-93. HUHS2002 activated CaMKII in cultured rodent hippocampal neurons, and this activation was abolished by KN-93. HUHS2002 also partially inhibited the activity of protein phosphatase 1 (PP1) in a cell-free PP1 activity assay .
Cat. No.: HY-N21792
CAS No.: 213842-42-3
Target:
Cat. No.: HY-W166106
CAS No.: 144631-82-3
Research Areas:
Bromoriluzole is a derivative of Riluzole (HY-B0211). Bromoriluzole inhibits Ca 2+ -dependent Calmodulin-SK4 channel interaction. Bromoriluzole is used for the research of neurodegenerative diseases .
Cat. No.: HY-114554
CAS No.: 103370-21-4
Category:
Target:
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
