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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
44 Results for "
DRG
" in MedChemExpress (MCE) Product Catalog:
Products (44)
44 Results for "DRG" in MCE Product Catalog:
Cat. No.: HY-P811941
Synonyms: C6orf55, HSPC228, My012, VTA1, Vacuolar protein sorting-associated protein VTA1 homolog, Dopamine-responsive gene 1 protein, LYST-interacting protein 5, SKD1-binding protein 1, DRG-1, LIP5, SBP1
Cat. No.: HY-P811941A
Synonyms: C6orf55, HSPC228, My012, VTA1, Vacuolar protein sorting-associated protein VTA1 homolog, Dopamine-responsive gene 1 protein, LYST-interacting protein 5, SKD1-binding protein 1, DRG-1, LIP5, SBP1
Cat. No.: HY-P70886
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NDRG1; Protein NDRG1; Prev. CAP43; Protein Regulated By Oxygen-1; DRG1; PROXY1; RTP; CMT4D; TDD5; HMSNL; NDR1; RIT42; Reducing Agents And Tunicamycin-Responsive Protein; TARG1; N-Myc Downstream-Regulated Gene 1 Protein; Rit42; Nickel-Specific Induction Pr
Species:
Human
Source:
E. coli
Cat. No.: HY-109061A
CAS No.: 2411549-88-5
Synonyms: YH25448 mesylate hydrate; GNS-1480 mesylate hydrate
Lazertinib (YH25448; GNS-1480) mesylate hydrate is an orally active, blood-brain barrier permeable third-generation EGFR tyrosine kinase inhibitor, as well as an ABCB1/ABCG2 inhibitor and a TRPA1 activator. Lazertinib mesylate hydrate exhibits IC50 values of 0.4 mM and 0.2 mM against human ABCB1 and ABCG2, respectively. By inhibiting mutant EGFR signaling, EGFR phosphorylation and the downstream ERK/AKT pathway, as well as upregulating surface expression of EGFR/MET, Lazertinib mesylate hydrate induces cell cycle arrest, apoptosis, spontaneous calcium responses, hyperexcitability of dorsal root ganglion (DRG) neurons, and TRPA1-dependent pain-like behaviors. Lazertinib mesylate hydrate competitively binds to the substrate-binding sites of ABCB1/ABCG2, stimulates their ATPase activity without altering their expression or plasma membrane localization, thereby enhancing ADCC activity, acting as a chemosensitizer, and reversing ABCB1-mediated multidrug resistance. It exerts antitumor activity as a single agent or in combination with other drugs. Lazertinib mesylate hydrate is applicable to research related to non-small cell lung cancer, multidrug-resistant cancers, and paresthesia .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
