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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
69 Results for "
Notch1
" in MedChemExpress (MCE) Product Catalog:
Products (69)
69 Results for "Notch1" in MCE Product Catalog:
Cat. No.: HY-10585AS
CAS No.: 1189994-89-5
Synonyms: Sodium Valproate-d7; VPA-d7 sodium; 2-Propylpentanoic acid-d7 sodium
Cat. No.: HY-141876
CAS No.: 2278356-90-2
Research Areas:
PRT543 is an orally active selective PRMT5 inhibitor. PRT543 reduces intracellular symmetric dimethylarginine (sDMA) levels, downregulates the expression of genes related to DNA damage repair and DNA replication pathways, and induces abnormal alternative splicing. PRT543 inhibits the MYB, NOTCH1 and PI3K/AKT signaling pathways, promotes nuclear translocation of FOXO1, upregulates the pro-apoptotic protein BAX, and enhances cellular sensitivity to BCL-2 inhibition. PRT543 disrupts the normal RNA splicing process and exerts a synthetic lethal effect on myeloid tumor cells carrying splicing factor mutations. PRT543 can be used in research related to various cancers including breast cancer, ovarian cancer and acute myeloid leukemia [1] .
Cat. No.: HY-10585S3
Synonyms: Sodium Valproate-d4; VPA-d4 sodium; 2-Propylpentanoic acid-d4 sodium
Cat. No.: HY-120372
CAS No.: 1584631-89-9
BMS-871 is an orally active pan-Notch inhibitor with IC50 values of 4/1/4/3 nM for Notch1/2/3/4, respectively. BMS-871 significantly inhibited the proliferation of TALL-1 and MDA-MB-157 cells and demonstrated significant antitumor activity in T-acute lymphoblastic leukemia and triple-negative breast cancer xenograft models. BMS-871 can be used to study leukemia and breast cancer [1].
Cat. No.: HY-P704827
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Notch1; Notch Homolog 1, Translocation-Associated; Prev. TAN1; Truncated Notch1; Notch 1; Notch1 Variant; Neurogenic Locus Notch Homolog Protein 1; Notch1 Protein; Translocation-Associated Notch Protein TAN-1; Mutant Notch 1; HN1; AOVD1; Notch (Drosophila
Species:
Human
Source:
HEK293
Cat. No.: HY-P78184
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: Notch1; Notch Homolog 1, Translocation-Associated; Prev. TAN1; Truncated Notch1; Notch 1; Notch1 Variant; Neurogenic Locus Notch Homolog Protein 1; Notch1 Protein; Translocation-Associated Notch Protein TAN-1; Mutant Notch 1; HN1; AOVD1; Notch (Drosophila
Species:
Human
Source:
HEK293
Cat. No.: HY-P78501
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: Notch1; Notch Homolog 1, Translocation-Associated; Prev. TAN1; Truncated Notch1; Notch 1; Notch1 Variant; Neurogenic Locus Notch Homolog Protein 1; Notch1 Protein; Translocation-Associated Notch Protein TAN-1; Mutant Notch 1; HN1; AOVD1; Notch (Drosophila
Species:
Human
Source:
HEK293
Cat. No.: HY-P79173
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Notch1; Notch Homolog 1, Translocation-Associated; Prev. TAN1; Truncated Notch1; Notch 1; Notch1 Variant; Neurogenic Locus Notch Homolog Protein 1; Notch1 Protein; Translocation-Associated Notch Protein TAN-1; Mutant Notch 1; HN1; AOVD1; Notch (Drosophila
Species:
Mouse
Source:
CHO
Cat. No.: HY-N0232R
CAS No.: 18642-23-4
Cat. No.: HY-P71166
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Notch1; Notch Homolog 1, Translocation-Associated; Prev. TAN1; Truncated Notch1; Notch 1; Notch1 Variant; Neurogenic Locus Notch Homolog Protein 1; Notch1 Protein; Translocation-Associated Notch Protein TAN-1; Mutant Notch 1; HN1; AOVD1; Notch (Drosophila
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P73324
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Notch1; Notch Homolog 1, Translocation-Associated; Prev. TAN1; Truncated Notch1; Notch 1; Notch1 Variant; Neurogenic Locus Notch Homolog Protein 1; Notch1 Protein; Translocation-Associated Notch Protein TAN-1; Mutant Notch 1; HN1; AOVD1; Notch (Drosophila
Species:
Mouse
Source:
Sf9 insect cells
Cat. No.: HY-P73742
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Notch1; Notch Homolog 1, Translocation-Associated; Prev. TAN1; Truncated Notch1; Notch 1; Notch1 Variant; Neurogenic Locus Notch Homolog Protein 1; Notch1 Protein; Translocation-Associated Notch Protein TAN-1; Mutant Notch 1; HN1; AOVD1; Notch (Drosophila
Species:
Human
Source:
HEK293
Synonyms: Tangeritin (Standard); NSC53909 (Standard); NSC618905 (Standard)
Category:
Target:
Cat. No.: HY-N9790
CAS No.: 79907-44-1
Target:
Cat. No.: HY-124284R
CAS No.: 3073-59-4
Synonyms: HMBA (Standard)
Target:
Apoptosis p38 MAPK Akt NF-κB Notch Bcl-2 Family MDM-2/p53 Epigenetic Reader Domain Reference Standards
Research Areas:
Hexamethylene bisacetamide (Standard) is the analytical standard of Hexamethylene bisacetamide. This product is intended for research and analytical applications. Hexamethylene bisacetamide (HMBA) is a differentiation inducer and selective bromine domain inhibitor that can differentiate across the blood-brain barrier. Hexamethylene bisacetamide can induce tumor cell differentiation and inhibit cell proliferation, showing antitumor activity. Hexamethylene bisacetamide induces apoptosis by Notch1, Bcl-2 and p53 signaling pathways. In addition, Hexamethylene bisacetamide improves the obesity phenotype of mice [1] .
Cat. No.: HY-P991328
Cat. No.: HY-181975
CAS No.: 956181-19-4
ATOX1-IN-1 is an inhibitor of ATOX1 (a copper chaperone protein) with a Kd value of 12.5 μM. ATOX1-IN-1 induces intracellular copper accumulation, increases the level of DNA methylation in the NOTCH1 promoter region, and inhibits the NOTCH1/HES1 signaling pathway. ATOX1-IN-1 enhances the sensitivity of hepatocellular carcinoma cells to Cisplatin (HY-17394). ATOX1-IN-1 can be used in hepatocellular carcinoma-related research [1].
Cat. No.: HY-164466A
CAS No.: 2682205-21-4
Target:
Research Areas:
CAD204520 dihydrochloride, a SERCA inhibitor (IC50 = 0.34 μM), targets mutated over wild type NOTCH1 proteins in T-cell acute lymphoblastic leukemia (T-ALL) and mantle cell lymphoma (MCL). CAD204520 dihydrochloride can be used for T-ALL and MCL research [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
