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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
44 Results for "
VCP
" in MedChemExpress (MCE) Product Catalog:
Products (44)
44 Results for "VCP" in MCE Product Catalog:
Cat. No.: HY-P7818
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CPVL; VCP-Like Protein; Carboxypeptidase Vitellogenic Like; HVLP; Vitellogenic Carboxypeptidase-Like Protein; Putative Serine Carboxypeptidase CPVL; Probable Serine Carboxypeptidase CPVL; Uncharacterized Protein CPVL; Carboxypeptidase, Vitellogenic-Like;
Species:
Human
Source:
HEK293
Cat. No.: HY-P701435
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: VCPIP1; Valosin Containing Protein Interacting Protein 1; VCIP135; KIAA1850; DUBA3; Valosin-Containing Protein P97/P47 Complex-Interacting Protein P135; Valosin-Containing Protein P97/P47 Complex-Interacting Protein 1; VCP/P47 Complex-Interacting 135-KDa
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P701436
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: VCPIP1; Valosin Containing Protein Interacting Protein 1; VCIP135; KIAA1850; DUBA3; Valosin-Containing Protein P97/P47 Complex-Interacting Protein P135; Valosin-Containing Protein P97/P47 Complex-Interacting Protein 1; VCP/P47 Complex-Interacting 135-KDa
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-112364
CAS No.: 1177741-83-1
Target:
SphK Dihydroceramide Desaturase 1 (DES1) Apoptosis Reactive Oxygen Species (ROS) mTOR PERK Keap1-Nrf2
Research Areas:
SKI-II hydrochloride is an orally active dual-target inhibitor of SphK1/2 and DES1, with Ki values of 16 µM and 0.3 µM against SphK1 and DES1, respectively. SKI-II hydrochloride activates the PERK-Nrf2 antioxidant pathway by stabilizing Nrf2, and synergizes with Temozolomide (HY-17364) to induce oxidative/endoplasmic reticulum stress and cancer cell death under hypoxic conditions. SKI-II hydrochloride inhibits SphK activity, promotes ceramide accumulation and apoptosis, and synergizes with Cisplatin (HY-17394) to reverse drug resistance via the ras/MAPK pathway in vivo. SKI-II hydrochloride reduces measles virus replication by inhibiting mTORC1 activity. SKI-II hydrochloride binds to VCP to induce M1 polarization, enhances host tolerance to Staphylococcus aureus infection, and exerts radioprotective effects through Nrf2 activation and accelerated DNA repair. SKI-II hydrochloride can be used in research related to glioblastoma, acute myeloid leukemia, gastric cancer, measles virus infection, Staphylococcus aureus infection, and acute radiation syndrome .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
