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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
83 Results for "
degranulation
" in MedChemExpress (MCE) Product Catalog:
Products (83)
83 Results for "degranulation" in MCE Product Catalog:
Cat. No.: HY-101225
CAS No.: 1451210-48-2
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Research Areas:
8 Hydroxy PIPAT oxalate is a 5-HT1A receptor agonist that promotes histamine release. 8 Hydroxy PIPAT oxalate selectively activates 5-HT1A receptors, thereby triggering mast cell degranulation and histamine release. 8 Hydroxy PIPAT oxalate is applicable to research related to irritable bowel syndrome .
Cat. No.: HY-161815
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Anti-inflammatory agent 89 is a multi-target glucocorticoid-isothiocyanate hybrid with anti-inflammatory activity. Anti-inflammatory agent 89 releases hydrogen sulfide via its isothiocyanate group, inhibits antigen-induced mast cell degranulation, alleviates pulmonary inflammation, and suppresses bronchial hyperresponsiveness and airway fibrosis. Anti-inflammatory agent 89 can be used in asthma research .
Cat. No.: HY-P2442
CAS No.: 95648-98-9
Cat. No.: HY-U00168
CAS No.: 76239-32-2
Synonyms: AL136
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KP136 (AL136) is an orally effective antiallergic agent. The IC50 is 76.1 μg/mL for histamine release and 63 ug/mL for degranulation .
Cat. No.: HY-106306
CAS No.: 90749-32-9
Synonyms: S 9795
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Laprafylline (S 9795), a xanthine derivative, is a bronchodilator. Laprafylline has potent anti-bronchoconstrictive effects, inhibiting action on mast cell degranulation and phosphodiesterase (PDE) activity (IC50 of 6 μM) .
Cat. No.: HY-N4207R
CAS No.: 14348-21-1
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Cat. No.: HY-N15423
CAS No.: 18904-40-0
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Cat. No.: HY-N1684
CAS No.: 75567-38-3
Category:
Terpenoids Diterpenoids Plants Meliaceae Aglaia elliptifolia
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Cat. No.: HY-123014
CAS No.: 120772-66-9
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(Rac)-SC-45694 is a racemate of SC-45694. SC-45694 has full LTB4 agonist activity for neutrophil chemotaxis and has antagonist activity against LTB4-induced neutrophil degranulation .
Cat. No.: HY-P11128
CAS No.: 1427516-68-4
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Cat. No.: HY-N2344R
CAS No.: 103883-03-0
Synonyms: Proanthocyanidin A1 (Standard)
Category:
other families Flavonoids Phenols Polyphenols Plants Biflavones
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Cat. No.: HY-158316
CAS No.: 2758569-43-4
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BTL-MK (Compound 19) an orally active antiallergic agent, that inhibits degranulation of mast cells with an IC50 of 6.7 μM, through binding to the inhibitory receptor FcγRIIB. BTL-MK improves the metaboilic stability in human liver microsomes. BTL-MK ameliorates the allergic response in Ovalbumin, low endotoxin (HY-W250978A)-induced food allergy mice model. BTL-MK exhibits a good pharmacokinetic character with metabolic stability .
Cat. No.: HY-N16668
CAS No.: 718638-77-8
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Cat. No.: HY-111198
CAS No.: 887647-69-0
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YM-355179 fumarate is a newly synthesized selective CCR3 antagonist with the potential to inhibit eosinophil-related allergic inflammatory diseases. YM-355179 can effectively inhibit the binding of CCL11 and CCL5 to CCR3-expressing cells, with IC50 values of 7.6 nM and 24 nM respectively. In functional experiments, YM-355179 can inhibit CCL11-induced intracellular Ca(2+) influx, chemotaxis and eosinophil degranulation, IC50 The values are 8.0 nM, 24 nM and 29 nM respectively .
Cat. No.: HY-N0078R
CAS No.: 20261-38-5
Synonyms: Ginkgolic acid (13:0) (Standard); Ginkgoneolic Acid (Standard); 6-Tridecylsalicylic acid (Standard)
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Category:
Cat. No.: HY-N8593S
CAS No.: 164858-54-2
Cat. No.: HY-13568R
CAS No.: 51234-28-7
Synonyms: LRCL 3794 (Standard)
Research Areas:
Benoxaprofen (Standard) is the analytical standard of Benoxaprofen. This product is intended for research and analytical applications. Benoxaprofen (LRCL 3794) is a nonsteroidal anti-inflammatory agent that blocks the biosynthesis of inflammatory mediators such as leukotrienes and prostaglandins by inhibiting 5-LOX, PGH2 synthase and cytochrome P-450. Benoxaprofen exhibits significant toxicity: it not only alters cellular redox status, uncouples oxidative phosphorylation and disrupts calcium ion homeostasis, but also causes liver injury through the formation of covalent adducts between its active metabolites and hepatic proteins. Benoxaprofen shows strong phototoxicity under ultraviolet irradiation, and induces erythrocyte lysis, mast cell degranulation and histamine release. Benoxaprofen is widely used in studies of urticaria and related phototoxic mechanisms .
Cat. No.: HY-W778179
CAS No.: 1329840-53-0
Synonyms: LRCL 3794-13C,d3
Cat. No.: HY-189392
Research Areas:
DAT-003 is a MRGPRX2 antagonist that selectively blocks MRGPRX2-mediated, IgE-independent mast cell degranulation without affecting IgE-dependent activation. DAT-003 can be used in studies of mast cell-related diseases, such as chronic spontaneous urticaria .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
