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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
122 Results for "
time-dependent
" in MedChemExpress (MCE) Product Catalog:
Products (122)
122 Results for "time-dependent" in MCE Product Catalog:
Cat. No.: HY-144689
CAS No.: 3033413-58-7
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BChE-IN-3 (compound 45a) is a potent, selective, time-dependent and pseudoirreversible BChE inhibitor, with an IC50 of 56.9 nM. BChE-IN-3 also shows marginal and reversible (not time-dependent) inhibition of AChE .
Cat. No.: HY-106855
CAS No.: 123955-10-2
Synonyms: H 234/09
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Almokalant is a class III antiarrhythmic agent, acts as a potassium channel blocker, and inhibits a specific component (Ikr) of the time-dependent delayed rectifier K + current.
Cat. No.: HY-176160
Synonyms: Methyl jacarate; SFE 19:3
Jacaric acid methyl ester is a methyl ester form of the conjugated PUFA jacaric acid. Jacaric acid can induce apoptosis selectively in human prostate cancer cells. Jacaric acid induces concentration- and time-dependent LNCaP cell death. Jacaric acid methyl ester can be studied in anticancer research .
Cat. No.: HY-D1527
CAS No.: 60354-76-9
Cat. No.: HY-122653
CAS No.: 2229856-58-8
CCT367766 is a pirin PROTAC degrader. CCT367766 forms a ternary complex with cereblon and induces pirin depletion via the ubiquitin-proteasome pathway in a concentration- and time-dependent manner. CCT367766 can be used for ovarian cancer research .
Cat. No.: HY-P4302
CAS No.: 118253-05-7
Synonyms: Z-Phe-Lys-2,4,6-Trimethylbenzoyloxy-methylketone
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Cat. No.: HY-170962
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SDUY817 is a dual APN/NEP inhibitor, with IC50 values of 0.29 μM for APN and 7.4 μM for NEP. SDUY817 exerts analgesic effects in a concentration- and time-dependent manner, and can be used for research in the field of neuropathic pain disorders .
Cat. No.: HY-18642A
Synonyms: (R)-PF-4981517
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(R)-CYP3cide ((R)-PF-4981517) is the R-isomer of CYP3cide (HY-18642). CYP3cide is a potent, selective and time-dependent inhibitor of cytochrome P4503A4 (CYP3A4) .
Cat. No.: HY-149036
Cat. No.: HY-115750
CAS No.: 139461-37-3
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Nω-allyl-L-arginine is a competitive and reversible inhibitor of bovine brain nitric oxide synthase (nNOS). Nω-allyl-L-arginine can inactivate nNOS in a time-dependent manner. Nω-allyl-L-arginine also is a substrate, producing L-arginine, acrolein, and H2O .
Cat. No.: HY-B0363S
CAS No.: 1330180-22-7
Cat. No.: HY-B0363R
CAS No.: 51803-78-2
Synonyms: R805 (Standard)
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Nimesulide (Standard) is the analytical standard of Nimesulide. This product is intended for research and analytical applications. Nimesulide is a selective COX-2 inhibitor, with IC50s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC50 >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties.
Cat. No.: HY-108704
CAS No.: 1388710-60-8
CT-721 is a potent and time-dependent Bcr-Abl kinase inhibitor with an IC50 of 21.3 nM for wild-type Bcr-Abl kinase, and possesses anti-chronic myeloid leukemia (CML) activities . CT-721 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-12519S
CAS No.: 2012598-51-3
Synonyms: RP 35972-d3; NSC 347901-d3
Cat. No.: HY-B0363S1
Synonyms: R805-13C6
Cat. No.: HY-12519R
CAS No.: 64224-21-1
Synonyms: RP 35972 (Standard); NSC 347901 (Standard)
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Oltipraz (Standard) is the analytical standard of Oltipraz. This product is intended for research and analytical applications. Oltipraz has an inhibitory effect on HIF-1α activation in a time-dependent manner, completely abrogating HIF-1α induction at ≥10 μM concentrations, the IC50 of Oltipraz for HIF-1α inhibition is 10 μM. Oltipraz is a potent Nrf2 activator.
Cat. No.: HY-100740A
CAS No.: 1383986-31-9
Synonyms: AZD-3293 hydrochloride; LY3314814 hydrochloride
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Lanabecestat (AZD3293; LY3314814) hydrochloride is a potent BACE1 inhibitor that has been investigated for its potential as a modifying treatment for Alzheimer's disease. Lanabecestat (hydrochloride) demonstrated significant dose- and time-dependent reductions in concentrations of amyloid beta peptides in plasma, cerebrospinal fluid, and brain. Lanabecestat (hydrochloride) was also shown to produce reductions in Aβ neuritic plaque burden without demonstrating clinical benefits or slowing the progression of Alzheimer's disease pathophysiology.
Cat. No.: HY-118129
CAS No.: 55511-14-3
Synonyms: Ganwuweizic acid
Schisandronic acid is a triterpenoid antioxidant and anticancer agent extracted from Schisandra chinensis, which has potent cytotoxicity against human breast cancer cells, especially MCF-7. Schisandronic acid induces apoptosis and reduces cell viability in a time-dependent manner (MCF-7, IC50=8.06 μM). Schisandronic acid can upregulate active caspase-3 expression and cleave PARP, reduce the generation of reactive oxygen species and exhibit antioxidant effects .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
