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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
43 Results for "
Rhodamine structure
" in MedChemExpress (MCE) Product Catalog:
Products (43)
43 Results for "Rhodamine structure" in MCE Product Catalog:
Cat. No.: HY-D3437
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Research Areas:
LRhod-PM is a photo-activated plasma membrane fluorescent probe based on a self-initiating photo-oxidation cascade mechanism. LRhod-PM, a non-fluorescent reduced rhodamine, is oxidized to the fluorescent form Rhod-PM upon visible light irradiation. LRhod-PM has maximum excitation and emission wavelengths of 560 nm and 585 nm, respectively. LRhod-PM enables wash-free labeling of the plasma membrane of living cells, including fine structures such as filopodia and tunneling nanotubes. LRhod-PM can be used in studies related to single-molecule localization super-resolution imaging of living cells .
Cat. No.: HY-D3401
CAS No.: 3121511-17-6
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Research Areas:
LHA585 is a fluorescent probe targeting the lipid hydrogen abstraction process for the early detection of ferroptosis (Ferroptosis). Its detection mechanism relies on the reactivity of its own 4-phenyl-3-methylbut-2-enyl moiety with biologically relevant oxidative radicals, including peroxyl radicals (ROO·), alkoxyl radicals (RO·), hydroxyl radicals (HO·), and peroxynitrite anions (ONOO−); upon hydrogen abstraction from this structure, radical rearrangement and radical cleavage occur, releasing a xanthene radical which converts into a highly fluorescent rhodamine dye in biological environments, thereby achieving a fluorescence turn-on ratio of up to 360-fold. LHA585 is non-fluorescent in its native state, possesses excellent membrane permeability due to its non-polar property, and the rhodamine dye generated after oxidation diffuses into mitochondria. The excitation wavelength of LHA585 is 561 nm, and its emission wavelength ranges from 570 to 620 nm .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
