![[Met(O)21] Corticotropin Releasing Factor, ovine](https://file.medchemexpress.com/product_pic/hy-p3685.gif "Click to View [Met(O)21] Corticotropin Releasing Factor, ovine Product Detail")
![[DPro5] Corticotropin Releasing Factor, human, rat](https://file.medchemexpress.com/product_pic/hy-p3684.gif "Click to View [DPro5] Corticotropin Releasing Factor, human, rat Product Detail")
Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
118 Results for "
hypothalamic
" in MedChemExpress (MCE) Product Catalog:
Products (118)
118 Results for "hypothalamic" in MCE Product Catalog:
Cat. No.: HY-B1811R
CAS No.: 11000-17-2
Synonyms: Arginine vasopressin (Standard); Antidiuretic hormone (Standard)
Category:
Cat. No.: HY-P1915
CAS No.: 600171-68-4
Target:
Research Areas:
Cat. No.: HY-A0287A
CAS No.: 57049-00-0
Synonyms: Clomifene hydrochloride; (Z/E)-Enclomiphene hydrochloride; (Z/E)-Enclomifene hydrochloride
Target:
Research Areas:
Clomiphene (Clomifene; (Z/E)-Enclomiphene; (Z/E)-Enclomifene) hydrochloride is an orally active ovulation-inducing agent. Clomiphene hydrochloride binds to hypothalamic estrogen receptors to elevate FSH levels, and exhibits antiestrogenic or estrogenic properties. Clomiphene hydrochloride can induce erturbations during meiotic maturation and cytogenetic abnormalities in mouse oocytes. Clomiphene hydrochloride ameliorates memory impairment in PCOS models. Clomiphene hydrochloride mobilizes cytosolic calcium and reduces viability in prostate cancer cells. Clomiphene hydrochloride can be used for the research of polycystic ovary syndrome (PCOS) and prostate cancer .
Cat. No.: HY-129207
CAS No.: 925239-03-8
Target:
Research Areas:
Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor that stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis. JMV3002 is a potent ghrelin receptor antagonist with an IC50 value of 1.1 nM in vitro. 80 μg/kg, JMV3002 inhibits hexarelin-stimulated food intake by as much as 98% in rats. JMV3002 alone does not elicit growth hormone release nor does it inhibit hexarelin-stimulated growth hormone secretion when tested in infant rats at a dose of 160 μg/kg.
Cat. No.: HY-B0627A
CAS No.: 121369-64-0
Synonyms: 1,1-Dimethylbiguanide (glycinate)
Research Areas:
Metformin (1,1-Dimethylbiguanide) glycinate inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin glycinate exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin glycinate also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin glycinate regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .
Cat. No.: HY-B0627S1
Synonyms: 1,1-Dimethylbiguanide-13C2 hydrochloride
Cat. No.: HY-P3685
Target:
Research Areas:
Cat. No.: HY-121318
CAS No.: 74143-01-4
Target:
Research Areas:
LK-11 is a tropane derivative that inhibits the passive uptake of noradrenalin (NA) by hypothalamic synaptic vesicles in vitro, similar to cocaine .
Cat. No.: HY-P1303A
Target:
Research Areas:
Cat. No.: HY-P3684
CAS No.: 195628-97-8
Target:
Research Areas:
Cat. No.: HY-118064
CAS No.: 163059-33-4
Synonyms: LY-368975
Target:
Research Areas:
(R)-Thionisoxetine is a potent and selective inhibitor of central and peripheral norepinephrine (NE) uptake. (R)-thionisoxetine prevented hypothalamic NE depletion by 6-hydroxydopamine with an ED50 of 0.21 mg/kg. (R)-Thionisoxetine can be used for the research of a variety of diseases including depression and urinary incontinence .
Cat. No.: HY-118064A
CAS No.: 222961-65-1
Synonyms: LY-368975 hydrochloride
Target:
Research Areas:
(R)-Thionisoxetine hydrochloride (LY-368975 hydrochloride) is a potent and selective central and peripheral norepinephrine (NE) uptake inhibitor. (R)-Thionisoxetine hydrochloride prevents 6-hydroxydopamine-induced hypothalamic NE depletion with an ED50 of 0.21 mg/kg. (R)-Thionisoxetine hydrochloride can be used in the study of a variety of diseases, including depression and urinary incontinence .
Cat. No.: HY-P2277A
Research Areas:
Cat. No.: HY-15691A
CAS No.: 1322001-35-3
Target:
Research Areas:
PF-4455242 hydrochloride is an orally bioavailable, blood-brain barrier-permeable κ-opioid receptor (KOR) inhibitor. PF-4455242 hydrochloride blocks in vivo effects induced by KOR and MOR agonists, and elicits KOR-independent outward currents in ventral tegmental area neurons. PF-4455242 hydrochloride promotes energy expenditure and activates the hypothalamic mTOR pathway. PF-4455242 hydrochloride attenuates stress-induced behavioral effects and produces antidepressant-like effects. PF-4455242 hydrochloride can be used in studies related to pain, depression, addictive disorders, and obesity induced by estrogen withdrawal .
Cat. No.: HY-P4872
CAS No.: 909409-86-5
Target:
Research Areas:
Cat. No.: HY-121578
CAS No.: 58298-77-4
Synonyms: GDHB
Target:
Research Areas:
Agaridoxin (GDHB) is a blocker of catecholamine and adrenergic alpha-type receptors isolated from mushrooms. Agaridoxin activates adenylyl cyclase in rat hypothalamic membrane granules in the presence of guanosyl imide diphosphate (Gpp(NH)p) .
Cat. No.: HY-119332
CAS No.: 359436-56-9
Category:
Target:
Cat. No.: HY-129682
CAS No.: 74515-39-2
Research Areas:
LY125180 is a serotonin uptake inhibitor. LY125180 competitively inhibits the uptake of serotonin and norepinephrine by cortical synaptosomes and of dopamine by striatal synaptosomes, with Ki values of 0.06 μM, 2.2 μM and 2.5 μM respectively .
Cat. No.: HY-P3513A
CAS No.: 78658-39-6
Research Areas:
β-Neo-Endorphin acetate is an endogenous opioid peptide. β-Neo-Endorphin acetate is a hypothalamic "big" Leu-enkephalin of porcine origin. β-Neo-Endorphin acetate shows activation of the Erk1/2, MMP-2 and MMP-9 .
Cat. No.: HY-169451
CAS No.: 55658-71-4
Synonyms: HU-580
Target:
Research Areas:
Cannabidiolic acid methyl ester (HU-580) is an orally active cannabidiolic acid analogue. Cannabidiolic acid methyl ester can enhance the activation of 5-HT1A receptor and increase the expression of c-Fos and NeuN in specific hypothalamic nuclei of rats. Cannabidiolic acid methyl ester has anti-nausea, anti-anxiety and anti-injury effects .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
