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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
122 Results for "
thromboxane-a2
" in MedChemExpress (MCE) Product Catalog:
Products (122)
122 Results for "thromboxane-a2" in MCE Product Catalog:
Cat. No.: HY-106066
CAS No.: 76894-77-4
Synonyms: UK38485
Target:
Research Areas:
Dazmegrel (UK-38485) is a thromboxane synthetase inhibitor which inhibits Thromboxane A2 (TXA2) synthesis and exhibits antiplatelet vasodilator effects. Dazmegrel can be utilized in thrombosis research .
Cat. No.: HY-19249
CAS No.: 146731-14-8
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Z-335 sodium is an orally active thromboxane a2 (TXA2) receptor antagonist, with IC50 values of 29.9 nM and 32.5 nM for human and Guinea pig platelets, respectively [2].
Cat. No.: HY-18763A
CAS No.: 94135-04-3
Synonyms: Ibustrin sodium
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Research Areas:
Indobufen sodium is a platelet aggregation inhibitor. Indobufen sodium is a reversible platelet cyclooxygenase (Cox) activity inhibitor. Indobufen sodium suppresses thromboxane A2 (TxA2) synthesis. Indobufen sodium down-regulates tissue factor (TF) in monocytes .
Cat. No.: HY-101236
CAS No.: 117621-64-4
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ICI 192605 is a potent TXA2R (thromboxane A2 receptor) antagonist as cell signaling prostaglandin. ICI 192605 blocks contraction of isolated guinea pig trachea induced by U-46619 .
Cat. No.: HY-119890
CAS No.: 89667-40-3
Synonyms: CV-4151
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Isbogrel (CV-4151) is a potent selective inhibitor of thromboxane A2 synthase. Isbogrel has oral activity and inhibits blood TXA2 generation with an ID50 value of 0.04 mg/kg .
Cat. No.: HY-105120A
CAS No.: 87248-13-3
Synonyms: GR 32191 hydrochloride
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Research Areas:
Vapiprost hydrochloride (GR 32191 hydrochloride) is a thromboxane A2 receptor antagonist. Vapiprost hydrochloride (GR 32191 hydrochloride) inhibits the aggregation and ATP release stimulated with U-46619, collagen or arachidonic acid (AA) at an IC50 of less than 2.1×10 -8 M .
Synonyms: U-63557A
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Research Areas:
Furegrelate Sodium (U-63557A) is a potent, orally available, and selective thromboxane synthase inhibitor. Furegrelate Sodium inhibits human platelet microsomal thromboxane A2 (TxA2) synthase with an IC50 of 15 nM. Furegrelate Sodium is being developed as an antiplatelet agent [2].
Cat. No.: HY-106080
CAS No.: 85666-24-6
Synonyms: U-63557A free acid
Target:
Research Areas:
Furegrelate (U-63557A free acid) is a potent, orally available, and selective thromboxane synthase inhibitor. Furegrelate inhibits human platelet microsomal thromboxane A2 (TxA2) synthase with an IC50 of 15 nM. Furegrelate is being developed as an antiplatelet agent [2].
Cat. No.: HY-105120
CAS No.: 85505-64-2
Synonyms: GR 32191
Target:
Research Areas:
Vapiprost (GR 32191) is a thromboxane A2 receptor (TXA2 Receptor) antagonist. Vapiprost hydrochloride (GR 32191 hydrochloride) inhibits the aggregation and ATP release stimulated with U-46619, collagen or arachidonic acid (AA) at an IC50 of less than 2.1×10 -8 M .
Cat. No.: HY-18763S
Synonyms: Ibustrin-d5
Cat. No.: HY-160664
CAS No.: 1448452-22-9
Target:
Research Areas:
TP receptor antagonist-2 (example 7n) is a thromboxane A2 receptor (TP receptor) antagonist, with IC50 values of 5.64 and 5.27 μM for TPα and TPβ, respectively. TP receptor antagonist-2 inhibits platelet aggregation .
Target:
Cat. No.: HY-160615
CAS No.: 1448452-21-8
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Research Areas:
TP receptor antagonist-1 (compound 7m) is a thromboxane A2 receptor (TP receptor) antagonist, with IC50 values of 9.46 μM for TPa and 8.49 μM for TPb, respectively. TP receptor antagonist-1 can be used for the research of cardiovascular disease .
Cat. No.: HY-18763R
CAS No.: 63610-08-2
Synonyms: Ibustrin (Standard)
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Research Areas:
Indobufen (Standard) is the analytical standard of Indobufen. This product is intended for research and analytical applications. Indobufen is a platelet aggregation inhibitor. Indobufen is a reversible platelet cyclooxygenase (Cox) activity inhibitor. Indobufen suppresses thromboxane A2 (TxA2) synthesis. Indobufen down-regulates tissue factor (TF) in monocytes .
Cat. No.: HY-116431
CAS No.: 128719-90-4
Target:
Research Areas:
I-BOP is an agonist for thromboxane A2 receptor (TP) with a KD of 0.61 nM. I-BOP promotes proliferation through activation of PI3K pathway in vascular smooth muscle . I-BOP dose-dependently biphasicly affects the excitatory postsynaptic potential (e.p.s.p.) in hippocampal neurons [2].
Cat. No.: HY-117842
CAS No.: 172544-75-1
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Research Areas:
KY 234 is an orally effective inhibitor that targets thromboxane A2 production, with an IC50 of 5 μM. KY 234 significantly inhibits leukotriene D4 (LTD4), histamine, and antigen-induced bronchoconstriction in guinea pigs, with IC50 values of 6.0 mg/kg, 2.5 mg/kg, and 6.3 mg/kg, respectively .
Cat. No.: HY-106080AR
CAS No.: 85666-17-7
Synonyms: U-63557A (Standard)
Research Areas:
Furegrelate (sodium) (Standard) is the analytical standard of Furegrelate (sodium). This product is intended for research and analytical applications. Furegrelate Sodium (U-63557A) is a potent, orally available, and selective thromboxane synthase inhibitor. Furegrelate Sodium inhibits human platelet microsomal thromboxane A2 (TxA2) synthase with an IC50 of 15 nM. Furegrelate Sodium is being developed as an antiplatelet agent [2].
Cat. No.: HY-176022
Target:
Research Areas:
U-46619 serinol amide is a derivative of U-46619 (HY-108566). U-46619 serinol amide is a stable analog of Thromboxane A2 (HY-113350) (TXA2). U-46619 serinol amide is a potent TXA2 agonist that can induce platelet shape change and aggregation .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
