85666-24-6
85666-24-6
Chemical Structure
Furegrelate
Synonym(s): U-63557A free acid
- CAS No.: 85666-24-6
- Formula:C15H11NO3
- Molecular Weight:253.25
IUPAC Name: 5-(pyridin-3-ylmethyl)benzofuran-2-carboxylic acid
InChIKey: VHWFITPGPFLBGT-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=CC(CC3=CC=CN=C3)=CC=C2O1)O
Biological Activity: Furegrelate (U-63557A free acid) is a potent, orally available, and selective thromboxane synthase inhibitor. Furegrelate inhibits human platelet microsomal thromboxane A2 (TxA2) synthase with an IC50 of 15 nM. Furegrelate is being developed as an antiplatelet agent[1][2].
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Furegrelate | Furegrelate (U-63557A free acid) is a potent, orally available, and selective thromboxane synthase inhibitor. Furegrelate inhibits human platelet microsomal thromboxane A2 (TxA2) synthase with an IC50 of 15 nM. Furegrelate is being developed as an antiplatelet agent. | |||||||||||||||||||||
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References
- [1]. Gorman RR, et al. Inhibition of platelet thromboxane A2 synthase activity by sodium 5-(3'-pyridinylmethyl)benzofuran-2-carboxylate. Prostaglandins. 1983 Aug;26(2):325-42. [Content Brief]
- [2]. Hirenallur-S DK, et al. Furegrelate, a thromboxane synthase inhibitor, blunts the development of pulmonary arterial hypertension in neonatal piglets. Pulm Circ. 2012 Apr-Jun;2(2):193-200. [Content Brief]
Keywords
