TP receptor antagonist-1
TP receptor antagonist-1 (compound 7m) is a thromboxane A2 receptor (TP receptor) antagonist, with IC50 values of 9.46 μM for TPa and 8.49 μM for TPb, respectively. TP receptor antagonist-1 can be used for the research of cardiovascular disease.
For research use only. We do not sell to patients.
- CAS No.: 1448452-21-8
- Formula: C17H16ClN3O4S
- Molecular Weight:393.84
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Thromboxane A2 receptor α (TPa) 9.46 μM (IC50) |
Thromboxane A2 receptor β (TPb) 8.49 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
8.49 μM
Compound: 7m
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Antagonist activity at human thromboxane A2 receptor beta over-expressed in HEK293 cells assessed as inhibition of U-46619-induced intracellular calcium mobilization mobilization by fluorescence assay
Antagonist activity at human thromboxane A2 receptor beta over-expressed in HEK293 cells assessed as inhibition of U-46619-induced intracellular calcium mobilization mobilization by fluorescence assay
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[PMID: 23688698] |
| HEK293 | IC50 |
9.46 μM
Compound: 7m
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Antagonist activity at human thromboxane A2 receptor alpha over-expressed in HEK293 cells assessed as inhibition of U-46619-induced intracellular calcium mobilization by fluorescence assay
Antagonist activity at human thromboxane A2 receptor alpha over-expressed in HEK293 cells assessed as inhibition of U-46619-induced intracellular calcium mobilization by fluorescence assay
|
[PMID: 23688698] |
TP receptor antagonist-1 (compound 7m) (10-5-10-7 M, 3 min) shows inhibitory effect on human platelet aggregationin vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1448452-21-8
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Molecular Weight 393.84
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Formula C17H16ClN3O4S
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SMILES
CC(NC(NS(=O)(C1=C(OC2=CC=C(Cl)C=C2)C=CC(C#N)=C1)=O)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TP receptor antagonist-1 Related Classifications
HY-160615 Related Classifications
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