81 Results for "

CCL2

" in MedChemExpress (MCE) Product Catalog:
Products (81)

81 Results for "CCL2" in MCE Product Catalog:

Cat. No.: HY-B1203S
Synonyms: 9α-Fludrocortisone-d5; 9α-Fluorcortisol-d5
Fludrocortisone-d5 (9α-Fludrocortisone-d5) is the deuterium labeled Fludrocortisone (HY-B1203). Fludrocortisone is an orally active mineralocorticoid and glucocorticoid receptor agonist. Fludrocortisone suppresses pro-inflammatory cytokine expression, reduces CCL2, IL-6, IL-8 levels, upregulates mineralocorticoid receptor (MR) expression, induces PI3K/Akt, GSK-3β, CREB, ERK1/2, mTOR phosphorylation, blocks Tau hyperphosphorylation, prevents apoptosis, promotes survival and proliferation, enhances renal sodium and water transport, increases plasma volume and blood pressure, reduces plasma potassium and renin activity, stimulates erythropoietin expression, modulates uterine receptivity genes, and reverses PP242-induced MUC1 upregulation. Fludrocortisone can be used for the research of congenital adrenal hyperplasia, postural hypotension, and adrenal insufficiency.
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Cat. No.: HY-B1203S1
Synonyms: 9α-Fludrocortisone-d2; 9α-Fluorcortisol-d2
Fludrocortisone-d2 (9α-Fludrocortisone-d2) is the deuterium labeled Fludrocortisone (HY-B1203). Fludrocortisone is an orally active mineralocorticoid and glucocorticoid receptor agonist. Fludrocortisone suppresses pro-inflammatory cytokine expression, reduces CCL2, IL-6, IL-8 levels, upregulates mineralocorticoid receptor (MR) expression, induces PI3K/Akt, GSK-3β, CREB, ERK1/2, mTOR phosphorylation, blocks Tau hyperphosphorylation, prevents apoptosis, promotes survival and proliferation, enhances renal sodium and water transport, increases plasma volume and blood pressure, reduces plasma potassium and renin activity, stimulates erythropoietin expression, modulates uterine receptivity genes, and reverses PP242-induced MUC1 upregulation. Fludrocortisone can be used for the research of congenital adrenal hyperplasia, postural hypotension, and adrenal insufficiency.
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Cat. No.: HY-183423
CAS No.: 2271348-04-8
Target:  

CDK STAT Bcl-2 Family CCR

Research Areas:  

Cancer

MK256 is an orally active, selective CDK8 inhibitor and CDK19/cyclin C inhibitor with IC50 values of 2.5 nM and 3.3 nM, respectively. MK256 downregulates phosphorylated STAT1 (S727), STAT5 (S726), MCL-1 mRNA and CCL2 mRNA. MK256 exhibits anti-tumor activity in acute myeloid leukemia. MK256 can be used for the research of acute myeloid leukemia .
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Cat. No.: HY-180831
BRD4 D1-IN-3 (compound 39) is a potent, selective, and cell-active BRD4-D1 inhibitor (IC50 = 39 nM, Ki = 2.4 nM) with >1700-fold selectivity over BRD2-D1. BRD4 D1-IN-3 reduces the expression of pro-inflammatory chemokines CXCL1 and CCL2 in an LPS (HY-D1056)-mediated cellular model of liver inflammation. BRD4 D1-IN-3 can be used for liver inflammation research .
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Cat. No.: HY-177933
Target:  

CCR

mNOX-E36 is a murine-specific analogue of NOX-E36 (HY-148100), an anti-CCL-2 L-RNA aptamer that binds and neutralises the mouse chemokine CCL-2. mNOX-E36 reduces scarring in an experimental murine model of glaucoma filtration surgery (GFS). mNOX-E36 ameliorates lupus nephritis in mice. mNOX-E36 can be used for GFS and lupus nephritis research [2].
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Cat. No.: HY-163655
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Glutaminyl Cyclase Inhibitor 6 (compound BI-43) is a secretory glutaminyl cyclase (sQC) and golgi-resident glutaminyl cyclase (gQC) inhibitor with IC50 values of 0.012 0.040 µM, respectively. Glutaminyl Cyclase Inhibitor 6 has the potential for the research of Parkinson’s disease .
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Cat. No.: HY-B1322AS1
Synonyms: Amodiaquin-d10
Amodiaquine-d10 hydrochloride is deuterated labeled Amodiaquine (HY-B1322A). Amodiaquine (Amodiaquin), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect [2] .
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Cat. No.: HY-B1322BR
CAS No.: 69-44-3
Synonyms: Amodiaquin dihydrochloride (Standard)
Amodiaquine (dihydrochloride) (Standard) is the analytical standard of Amodiaquine (dihydrochloride). This product is intended for research and analytical applications. Amodiaquine dihydrochloride (Amodiaquin dihydrochloride), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor with a Ki of 18.6 nM. Amodiaquine dihydrochloride is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect [2] .
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Cat. No.: HY-P700231AF
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CCL2; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 2; Prev. SCYA2; Chemokine (C-C Motif) Ligand 2; MCP-1; Monocyte Chemotactic Protein 1; MCP1; Small-Inducible Cytokine A2; MCAF; C-C Motif Chemokine 2; HC11; MGC9434; Monocyte Chemotactic And Act
Species:  
Pig
Source:  
E. coli
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Cat. No.: HY-P72757
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CCL2; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 2; Prev. SCYA2; Chemokine (C-C Motif) Ligand 2; MCP-1; Monocyte Chemotactic Protein 1; MCP1; Small-Inducible Cytokine A2; MCAF; C-C Motif Chemokine 2; HC11; MGC9434; Monocyte Chemotactic And Act
Species:  
Mouse
Source:  
HEK293
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Cat. No.: HY-P78488
Purity:  ≥ 90%, as determined by Bis-Tris PAGE.
Synonyms: CCL2; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 2; Prev. SCYA2; Chemokine (C-C Motif) Ligand 2; MCP-1; Monocyte Chemotactic Protein 1; MCP1; Small-Inducible Cytokine A2; MCAF; C-C Motif Chemokine 2; HC11; MGC9434; Monocyte Chemotactic And Act
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P700034AF
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CCL2; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 2; Prev. SCYA2; Chemokine (C-C Motif) Ligand 2; MCP-1; Monocyte Chemotactic Protein 1; MCP1; Small-Inducible Cytokine A2; MCAF; C-C Motif Chemokine 2; HC11; MGC9434; Monocyte Chemotactic And Act
Species:  
Human
Source:  
E. coli
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Cat. No.: HY-P700787
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CCL2; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 2; Prev. SCYA2; Chemokine (C-C Motif) Ligand 2; MCP-1; Monocyte Chemotactic Protein 1; MCP1; Small-Inducible Cytokine A2; MCAF; C-C Motif Chemokine 2; HC11; MGC9434; Monocyte Chemotactic And Act
Species:  
Cynomolgus
Source:  
HEK293
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Cat. No.: HY-185153
Research Areas:  

Cancer

MC-VC-PAB-DMEA-PEG2-Duocarmycin SA is a drug-linker conjugate for ADC. MC-VC-PAB-DMEA-PEG2-Duocarmycin SA can be coupled with Carlumab (HY-P99188) to form Anti-CCL2 (Carlumab)-MC-Vc-PAB-DMEA-PEG2-Duocarmycin SA (HY-171685).
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Cat. No.: HY-144334
CAS No.: 2906132-49-6
Target:  

CHIKV DNA/RNA Synthesis

Research Areas:  

Infection

CHIKV-IN-3 is a potent against two low-passage CHIKV inhibitor with EC50 values of 1.55 and 0.14 μM for CHIKV-122508 and CHIKV-6708, respectively. CHIKV-IN-3 acts on the host cells to interfere with the viral replication. CHIKV-IN-3 displays minimal cytotoxic liability (CC50>100 μM). Prophylactic effect .
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Cat. No.: HY-P700164AF
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CCL2; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 2; Prev. SCYA2; Chemokine (C-C Motif) Ligand 2; MCP-1; Monocyte Chemotactic Protein 1; MCP1; Small-Inducible Cytokine A2; MCAF; C-C Motif Chemokine 2; HC11; MGC9434; Monocyte Chemotactic And Act
Species:  
Mouse
Source:  
E. coli
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Cat. No.: HY-P74758
Purity:  ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: CCL2; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 2; Prev. SCYA2; Chemokine (C-C Motif) Ligand 2; MCP-1; Monocyte Chemotactic Protein 1; MCP1; Small-Inducible Cytokine A2; MCAF; C-C Motif Chemokine 2; HC11; MGC9434; Monocyte Chemotactic And Act
Species:  
Mouse
Source:  
Sf9 insect cells
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Cat. No.: HY-P76489
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CCL2; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 2; Prev. SCYA2; Chemokine (C-C Motif) Ligand 2; MCP-1; Monocyte Chemotactic Protein 1; MCP1; Small-Inducible Cytokine A2; MCAF; C-C Motif Chemokine 2; HC11; MGC9434; Monocyte Chemotactic And Act
Species:  
Mouse
Source:  
Sf9 insect cells
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Cat. No.: HY-187365
Target:  

Glycosidase

Research Areas:  

Inflammation/Immunology

UCM-17017 is a tetrasubstituted cyclohexene inhibitor that inhibits the activity of senescent cell SA-β-gal with an IC50 of 0.4 μM. UCM-17017 selectively reduces the viability of senescent cancer cells, and this effect is stronger than its impact on proliferating cells. UCM-17017 binds to human serum albumin with a KD of 230 μM. UCM-17017 reduces collagen deposition and decreases the expression of the inflammatory marker Ccl2 in a mouse model of pulmonary fibrosis. UCM-17017 can be used in studies related to senescence and pulmonary fibrosis .
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Cat. No.: HY-P704401
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CCL2; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 2; Prev. SCYA2; Chemokine (C-C Motif) Ligand 2; MCP-1; Monocyte Chemotactic Protein 1; MCP1; Small-Inducible Cytokine A2; MCAF; C-C Motif Chemokine 2; HC11; MGC9434; Monocyte Chemotactic And Activating Factor; Monocyte Chemotactic Protein 1, Homologous To Mouse Sig-Je; Monocyte Secretory Protein JE; Chemokine (C-C Motif) Ligand 2, Isoform CRA_a; SMC-CF; Monocyte Chemoattractant Protein 1; GDCF-2; HSMCR30; Small Inducible Cytokine A2 (Monocyte Chemotactic Protein 1, Homologous To Mouse Sig-Je); C-C Motif Chemokine Ligand 2; Monocyte Chemoattractant Protein-1
Species:  
Human
Source:  
HEK293
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