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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
81 Results for "
nonstructural
" in MedChemExpress (MCE) Product Catalog:
Products (81)
81 Results for "nonstructural" in MCE Product Catalog:
Cat. No.: HY-P811944A
Synonyms: TBC1D23; TBC1 Domain Family Member 23; HCV Non-Structural Protein 4A-Transactivated Protein 1; FLJ11046; NS4ATP1; HCV nonstructural Protein 4A-Transactivated Protein 1; TBC1 Domain Family, Member 23; PCH11
Cat. No.: HY-P991774
Target:
Research Areas:
Cat. No.: HY-P77831
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: Replicase polyprotein 1a; pp1a; ORF1a polyprotein; Host translation inhibitor nsp1; Leader protein, Non-structural protein 1 (nsp1); Non-structural protein 2 (nsp2); p65 homolog; Papain-like protease nsp3; EC:3.2.2.-; EC:3.4.19.12; EC:3.4.22.-; Non-struct
Species:
Virus
Source:
E. coli
Cat. No.: HY-P702190
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Replicase polyprotein 1a; pp1a; ORF1a polyprotein; Host translation inhibitor nsp1; Leader protein, Non-structural protein 1 (nsp1); Non-structural protein 2 (nsp2); p65 homolog; Papain-like protease nsp3; EC:3.2.2.-; EC:3.4.19.12; EC:3.4.22.-; Non-struct
Species:
Virus
Source:
E. coli
Cat. No.: HY-P703532
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: Replicase polyprotein 1ab; pp1ab; ORF1ab polyprotein; Host translation inhibitor nsp1; Leader protein; Non-structural protein 1 (nsp1); Non-structural protein 2 (nsp2); p65 homolog; Papain-like protease nsp3 (EC:3.2.2.-, EC:3.4.19.12, EC:3.4.22.-); Non-
Species:
Virus
Source:
E. coli
Cat. No.: HY-P703533
Synonyms: Replicase polyprotein 1ab; pp1ab; ORF1ab polyprotein; Host translation inhibitor nsp1; Leader protein; Non-structural protein 1 (nsp1); Non-structural protein 2 (nsp2); p65 homolog; Papain-like protease nsp3 (EC:3.2.2.-, EC:3.4.19.12, EC:3.4.22.-); Non-
Species:
Virus
Source:
E. coli
Cat. No.: HY-181680
CAS No.: 145294-59-3
Target:
Research Areas:
ATPase-IN-8 is an anti-enteroviral agent that inhibits the viral non-structural protein 2C, with an IC50 of 1.4 μM against CV-B3 2C ATPase. ATPase-IN-8 exhibits significant anti-enteroviral activity and acts as a potent, selective inhibitor of CV-B3 and EV-D68. ATPase-IN-8 can be used for research on enteroviral infections .
Cat. No.: HY-10246A
CAS No.: 847440-99-7
Target:
Research Areas:
A-837093 sodium is a potent and orally active inhibitor of the hepatitis C virus (HCV) nonstructural protein 5B (NS5B) polymerase. A-837093 sodium shows potencies against polymerases derived from both HCV genotypes 1a (IC50 = 1.25 nM) and 1b (IC50 = 0.33 nM). A-837093 sodium exhibits antiviral efficacy in HCV-infected chimpanzees. A-837093 sodium can be used for HCV infection research .
Cat. No.: HY-181920
Target:
Research Areas:
RPG-01-132 is a PROTAC degrader targeting the DENV capsid protein, with a DC50 of 2.4 μM. RPG-01-132 blocks viral assembly, eliminates viral particles, and interferes with the non-structural functions of the capsid protein. RPG-01-132 exhibits significant antiviral activity against all four DENV serotypes and the ST148 (HY-121663)-resistant DENV2 mutant strain. RPG-01-132 can be applied in studies related to dengue virus infection .
Cat. No.: HY-182317
CAS No.: 2043343-94-6
Target:
Research Areas:
(+)-Mosnodenvir is an isomer of Mosnodenvir (HY-153810). Mosnodenvir (JNJ-1802) is an orally active pan serotype dengue virus (DENV) inhibitor, with EC50 values ranging from 0.057 to 11 nM for four dengue virus (DENV) serotypes. Mosnodenvir blocks viral replication by inhibiting the formation of complexes between two viral proteins, nonstructural protein 3 (NS3) and NS4B, thereby preventing the formation of new viral RNA. Mosnodenvir exhibits picomolar to nanomolar antiviral activity in vitro and has antiviral efficacy in mice and non-human primates .
Cat. No.: HY-184263
CAS No.: 1309199-66-3
Target:
Research Areas:
CHVB-032 is an antiviral agent and SFV nsP1 inhibitor. CHVB-032 inhibits the methyltransferase and guanylyltransferase activities of nsP1, blocks viral RNA capping process, and suppresses post-entry steps in CHIKV replication. CHVB-032 inhibits CHIKV replication across different isolates, but shows no activity against other alphaviruses. CHVB-032 can be used in research related to chikungunya fever and CHIKV infection .
Cat. No.: HY-183761
Target:
Research Areas:
Antiviral agent 86 is an anti-coronavirus agent. Antiviral agent 86 acts as a binder of coronavirus non-structural protein 15 (nsp15), with a Kd value of 67 μM against human targets. Antiviral agent 86 inhibits the replication of HCoV-229E and SARS-CoV-2. Antiviral agent 86 exerts inhibitory effects at the post-entry lifecycle stage of coronaviruses in host cells and inhibits the formation of viral double-stranded RNA (dsRNA). Antiviral agent 86 exhibits an additive antiviral effect when used in combination with GS-441524. Antiviral agent 86 can be used in studies related to coronavirus infections .
Cat. No.: HY-114216
CAS No.: 1310694-75-7
Target:
Research Areas:
DBPR110 is a nonstructural protein 5A (NS5A) inhibitor with inhibitory activity against hepatitis C virus (HCV). DBPR110 exhibited a 50% effective concentration (EC50) of 3.9 ± 0.9 pM and a selectivity index value of over 12,800,000 by reducing HCV1b replicon reporter expression. DBPR110 also effectively reduced the activity of HCV2a replicon with an EC50 of 228.8 pM and a selectivity index value of over 173,130. DBPR110 showed synergy with interferon alpha (IFN-α), NS3 protease inhibitors, and NS5B polymerase inhibitors. The results of DBPR110 suggest that it may be an effective small molecule inhibitor against HCV NS5A .
Cat. No.: HY-P703397
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NSMCE1; NSE1; NSE1 Component Of SMC5/6 Complex; Non-SMC Element 1 Homolog; NSE1 Homolog, SMC5-SMC6 Complex Component; Non-SMC Element 1 Homolog (S. Cerevisiae); Non-Structural Maintenance Of Chromosomes Element 1 Homolog
Species:
Human
Source:
E. coli
Cat. No.: HY-P703398
Synonyms: NSMCE1; NSE1; NSE1 Component Of SMC5/6 Complex; Non-SMC Element 1 Homolog; NSE1 Homolog, SMC5-SMC6 Complex Component; Non-SMC Element 1 Homolog (S. Cerevisiae); Non-Structural Maintenance Of Chromosomes Element 1 Homolog
Species:
Human
Source:
E. coli
Cat. No.: HY-187508
Target:
Research Areas:
JNJ-2594 is an inhibitor of dengue virus (DENV) NS5 RNA-dependent RNA polymerase (RdRP). JNJ-2594 inhibits the elongation activity of DENV2 and DENV3 NS5 polymerases with IC50 values of 5.8 μM and 3.2 μM, respectively, and inhibits de novo RNA synthesis of DENV2 with an IC50 of 23.5 μM. JNJ-2594 exhibits cross-inhibitory effects on human mitochondrial RNA polymerase. JNJ-2594 can be used in research on the discovery of dengue virus NS5 polymerase and DENV RdRP inhibitors .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
