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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
105 Results for "
polycyclic
" in MedChemExpress (MCE) Product Catalog:
Products (105)
105 Results for "polycyclic" in MCE Product Catalog:
Cat. No.: HY-N21700
CAS No.: 1189125-05-0
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Cat. No.: HY-W096907
CAS No.: 213-46-7
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Picene is a polycyclic aromatic hydrocarbon of environmental relevance. Picene can be widely distributed in the environment as the result of incomplete combustion of organic matter. Picene is found to be inactive as complete carcinogen, while it acts in a high dose as a weak tumor initiator .
Cat. No.: HY-E72109
Human UGT1A7 is a UDP-glucuronosyltransferase. UGT1A7 catalyzes the glucuronidation of hydrophobic substrates, polycyclic aromatic hydrocarbons, dietary heterocyclic amines, and 1-Hydroxypyrene (HY-W014075). Human UGT1A7 is applicable to research related to sporadic colorectal cancer .
Cat. No.: HY-N21677
CAS No.: 2172833-78-0
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Cat. No.: HY-N21699
CAS No.: 1927024-53-0
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Cat. No.: HY-N21698
CAS No.: 1253206-38-0
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Cat. No.: HY-E72094
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Human CYP1A2, Reductase+b5 refers to a near-physiological recombinant microsomal system co-expressed in insect cells, consisting of human cytochrome P450 1A2, NADPH-P450 oxidoreductase (CPR) and cytochrome b5. Human CYP1A2 is a human cytochrome P450 subtype belonging to the CYP1 family, as well as a major metabolic enzyme. Its expression is centered in the human liver, and it can activate procarcinogens including aromatic heterocyclic amines and polycyclic aromatic hydrocarbons .
Cat. No.: HY-W587465
CAS No.: 17219-94-2
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9,10-Dichlorophenanthrene is a chlorinated polycyclic aromatic hydrocarbon and is generally regarded as a carcinogen. It could activate the aryl hydrocarbon receptor (AhR) .
Cat. No.: HY-W587560
CAS No.: 6344-67-8
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3-Hydroxyfluorene is a polycyclic aromatic hydrocarbon. 3-Hydroxyfluorene can be used for the study of psoriasis and non-alcoholic fatty liver disease.
Cat. No.: HY-N16458
CAS No.: 1316171-50-2
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Cat. No.: HY-111441R
CAS No.: 100900-16-1
Synonyms: Chrysene-1,4-dione (Standard)
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1,4-Chrysenequinone (Standard) is the analytical standard of 1,4-Chrysenequinone (HY-111441). This product is intended for research and analytical applications. 1,4-Chrysenequinone, a polycyclic aromatic quinone, acts as an activator of aryl hydrocarbon receptor (AhR).
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NSC 30973 is a monofunctional halomethyl polycyclic aromatic hydrocarbon alkylating agent. NSC 30973 exhibits antitumor activity against Ehrlich ascites tumor and S-37 ascites tumor. NSC 30973 can be used in the research of Ehrlich ascites tumor .
Cat. No.: HY-19197
CAS No.: 141577-40-4
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2-NAP is a major metabolite of polycyclic aromatic hydrocarbons (PAHs). 2-NAP induces oxidative stress and inflammatory responses, impairs enamel formation, and disrupts oral microbiome balance, increasing the risk of early childhood caries (ECC). 2-NAP is promising for research of development-related diseases such as childhood caries .
Cat. No.: HY-171982
CAS No.: 68857-95-4
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ATII (Traseolide), a Polycyclic musk fragrance, is a hydrophobic hapten. ATII has no genotoxicity in the human lymphocytes and the human hepatoma cell line Hep G2. ATII can be bound by antibody M02/05/01 (H93 Val) with superior binding capacity. ATII can be conjugated to carrier proteins for antigen design .
Cat. No.: HY-W011577
CAS No.: 215-58-7
Synonyms: Dibenz[a,c]anthracene
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Benzo[f]tetraphene (Dibenz[a,c]anthracene) is a polycyclic aromatic hydrocarbon with significant antitumor activity. Benzo[f]tetraphene is used as a luminescent probe in cell biology research and can effectively detect reactive oxygen species in biological systems. Benzo[f]tetraphene can also be used as a potential photosensitizer and shows good application prospects in photodynamic inhibition.
Cat. No.: HY-111450R
CAS No.: 819827-50-4
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CB7993113 (Standard) is the analytical standard of CB7993113 (HY-111450). This product is intended for research and analytical applications. CB7993113 is a potent AHR antagonist, with an IC50 of 0.33 μM. CB7993113 directly binds AHR protein and blocks AHR nuclear translocation. CB7993113 inhibits polycyclic aromatic hydrocarbon (PAH)- and TCDD-induced reporter activity by 75% and 90% respectively .
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Aceanthrenequinone is a polycyclic aromatic hydrocarbon quinone organic compound that belongs to the category of free radical photoinitiators. Aceanthrenequinone serves as an intermediate for dyes and pigments, and also acts as a substrate for organic synthesis and polymer materials. Aceanthrenequinone activates the Aryl Hydrocarbon Receptor pathway, induces the expression of CYP1A protein in the vascular system of zebrafish embryos, and causes the death of embryos at 120 hpf. Aceanthrenequinone is applicable to research related to industrial or biomedical applications .
Cat. No.: HY-E72103
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Human CYP1A1, Reductase+b5 refers to a near-physiological recombinant microsomal system co-expressed in insect cells, consisting of human cytochrome P450 1A1, NADPH-P450 oxidoreductase (CPR) and cytochrome b5. Human CYP1A1 is a human cytochrome P450 subtype belonging to the CYP1 family, as well as a major metabolic enzyme. Its expression is concentrated in tissues such as lung, breast, placenta and endometrium, and it can metabolize polycyclic aromatic hydrocarbons and estrogens into carcinogenic intermediates with DNA-damaging activity .
Cat. No.: HY-W585976
CAS No.: 58917-67-2
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Benzo[a]pyrene diol epoxide is a carcinogen present in tobacco smoke as well as in environmental pollution. Benzo[a]pyrene diol epoxide is a metabolite of benzo[a]pyrene (BaP) , which is polycyclic aromatic hydrocarbon (PAH) . Benzo[a]pyrene diol epoxide induces esophageal carcinogenesis. Benzo[a]pyrene diol epoxide may act to induce activation of ERKs and p38 MAPK marked by an increased level of phosphorylation of both the ERKs and p38 MAPK which corresponds with the increased activation of both kinases as evidenced by increased phsosphorylation of their substrates Elk-1 and ATF-2, respectively.
Cat. No.: HY-183242
CAS No.: 120154-96-3
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Eilatin is a seven-ring pyridoacridine marine alkaloid with anticancer, antibacterial, and antiparasitic activities. Eilatin acts as a DNA intercalator with selectivity for electron-deficient polycyclic purines; it can chelate Ni 2+ ions and cleave DNA via hydroxyl radical generation. Eilatin induces the SOS response in bacteria, inhibits cancer cell proliferation, and induces cancer cell differentiation and reversion of transformation. The IC50 of Eilatin against Trypanosoma brucei brucei is 1.33 μM. Eilatin can be used in research related to colon tumors, neuroblastoma, chronic myeloid leukemia, acute myeloid leukemia, and trypanosome infections .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
